Shanghai Key Laboratory of Molecular Imaging, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
Molecules. 2024 Jun 23;29(13):2980. doi: 10.3390/molecules29132980.
Microbial contamination has profoundly impacted human health, and the effective eradication of widespread microbial issues is essential for addressing serious hygiene concerns. Taking polystyrene (PS) membrane as an example, we herein developed report a robust strategy for the in situ preparation of chlorine-regenerable antimicrobial polymer molecular sieve membranes through combining post-crosslinking and nucleophilic substitution reaction. The cross-linking PS membranes underwent a reaction with 5,5-dimethylhydantoin (DMH), leading to the formation of polymeric -halamine precursors (PS-DMH). These hydantoinyl groups within PS-DMH were then efficiently converted into biocidal -halamine structures (PS-DMH-Cl) via a simple chlorination process. ATR-FTIR and XPS spectra were recorded to confirm the chemical composition of the as-prepared PS-DMH-Cl membranes. SEM analyses revealed that the chlorinated PS-DMH-Cl membranes displayed a rough surface with a multitude of humps. The effect of chlorination temperature and time on the oxidative chlorine content in the PS-DMH-Cl membranes was systematically studied. The antimicrobial assays demonstrated that the PS-DMH-Cl membranes could achieve a 6-log inactivation of and within just 4 min of contact time. Additionally, the resulting PS-DMH-Cl membranes exhibited excellent stability and regenerability of the oxidative chlorine content.
微生物污染深刻影响着人类健康，有效消除广泛存在的微生物问题对于解决严重的卫生问题至关重要。以聚苯乙烯（PS）膜为例，我们在此开发了一种通过后交联和亲核取代反应原位制备可氯再生抗菌聚合物分子筛膜的强大策略。交联 PS 膜与 5,5-二甲基海因（DMH）反应，形成聚合型卤胺前体（PS-DMH）。这些海因基（hydantoinyl groups）在 PS-DMH 中通过简单的氯化过程有效地转化为杀菌性卤胺结构（PS-DMH-Cl）。ATR-FTIR 和 XPS 光谱用于证实所制备的 PS-DMH-Cl 膜的化学组成。SEM 分析表明，氯化 PS-DMH-Cl 膜呈现出粗糙表面，有许多凸起。系统研究了氯化温度和时间对 PS-DMH-Cl 膜中氧化氯含量的影响。抗菌试验表明，PS-DMH-Cl 膜在接触时间仅 4 分钟内即可实现对数 6 灭活 和 。此外，所得 PS-DMH-Cl 膜表现出优异的氧化氯含量稳定性和可再生性。
