Unidad de Neonatología, Complejo Asistencial Universitario de Burgos, Burgos, Spain.
Unidad de Neonatología, Complejo Asistencial Universitario de Burgos, Burgos, Spain; Fundación NeNe, Madrid, Spain; Profesor Sociedad Iberoamericana de Neonatología, Nueva Yersey, EE.UU.
An Pediatr (Engl Ed). 2023 May;98(5):338-343. doi: 10.1016/j.anpede.2023.03.005. Epub 2023 Apr 17.
The objective of the study was to establish the normal range for the levels of antithrombin (AT), protein C (PC), and protein S (PS) in the first week post birth in mother-infant pairings, adjusting for obstetric and perinatal factors, based on 2 different laboratory methods.
Determinations were carried out in 83 healthy term neonates and their mothers, establishing 3 postpartum age groups: 1-2 days, 3 days, and 4-7 days.
There were no differences in the levels of any of the proteins between the different age groups in neonates or mothers in the first week post birth. The adjusted analysis found no association with obstetric or perinatal factors. The AT and PC levels were higher in mothers compared to infants (P < .001), while the PS levels were similar in both. Overall, the correlation of maternal and infant protein values was poor, except for the levels of free PS in the first 2 days after delivery. Although we found no differences based on which of the 2 laboratory methods was applied, the absolute values did differ.
本研究的目的是在调整产科和围产期因素的基础上，通过两种不同的实验室方法，确定母婴配对后出生后第一周抗凝血酶 (AT)、蛋白 C (PC) 和蛋白 S (PS) 水平的正常范围。
对 83 名健康足月新生儿及其母亲进行了测定，建立了 3 个产后年龄组：1-2 天、3 天和 4-7 天。
出生后第一周，新生儿和母亲的任何蛋白质在不同年龄组之间均无差异。调整分析发现与产科或围产期因素无关。与婴儿相比，母亲的 AT 和 PC 水平更高（P<0.001），而 PS 水平相似。总的来说，母亲和婴儿蛋白值的相关性较差，除了分娩后前两天游离 PS 水平外。虽然我们没有发现基于应用的 2 种实验室方法中的哪一种存在差异，但绝对值确实有所不同。
