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在日常临床实践中对可存活阶段妊娠的终止:比利时佛兰德斯的全国死亡率随访研究。

Pregnancy termination at a viable stage in daily clinical practice: A nationwide mortality follow-back study in Flanders, Belgium.

机构信息

Department of Obstetrics, Women's Clinic, University Hospital Ghent, Ghent, Belgium.

End-of-Life Care Research Group, Vrije Universiteit Brussel (VUB) & Ghent University, Ghent, Belgium.

出版信息

Prenat Diagn. 2023 Jun;43(6):781-791. doi: 10.1002/pd.6356. Epub 2023 Apr 26.

DOI:10.1002/pd.6356
PMID:37076971
Abstract

OBJECTIVE

Congenital malformations are frequently diagnosed prenatally even at a viable stage. No adequate registration of incidence and characteristics of late termination of pregnancy (TOP) or abortion for medical reasons exists in Flanders.

METHODS

Nationwide mortality follow-back survey sent to physicians signing death certificates of all stillbirths for 22 weeks gestation onward (September 2016-December 2017) in Flanders, Belgium. Questions measured whether late TOP preceded stillbirth, and which clinical and sociodemographic characteristics were indicated. Questionnaire data were linked with sociodemographic information from death certificates.

RESULTS

Response rate was 56% (203/366). 38% of stillbirths (77/203) concerned late TOP. In 88.3% of late TOPs, physicians classified congenital anomalies of the foetus as serious or very serious (incompatibility with life outside the womb or severe neurological or physical impairment). In 26% of cases, late TOP was first suggested by the physician rather than spontaneously requested by parents (73%). 88% of late TOPs were discussed in open team meetings.

CONCLUSIONS

2/5 stillbirths were preceded by late TOP, indicating severe underreportation by existing registrations and a dire need for adequate registration methods. Although late TOP was most often explicitly requested by parents, in ¼ cases termination was suggested first by physicians. Parents are sometimes hesitant to bring up late TOP themselves, indicating that TOP should always be counselled as an equivalent option.

摘要

目的

即使在可存活阶段,先天性畸形也经常在产前被诊断出来。在弗兰德斯,没有充分的登记来记录因医疗原因而终止妊娠(TOP)或流产的发生率和特征。

方法

对所有在 22 周妊娠后(2016 年 9 月至 2017 年 12 月)在比利时弗兰德斯签署所有死产死亡证明的医生进行全国性的死亡率随访调查。问题是衡量晚期 TOP 是否先于死产,以及哪些临床和社会人口统计学特征被指出。问卷调查数据与死亡证明中的社会人口统计学信息相关联。

结果

回应率为 56%(203/366)。38%的死产(77/203)与晚期 TOP 有关。在 88.3%的晚期 TOP 中,医生将胎儿的先天性异常分类为严重或非常严重(与子宫外生存不兼容或严重的神经或身体损伤)。在 26%的情况下,晚期 TOP 是由医生而非父母主动建议的(73%)。88%的晚期 TOP 是在开放团队会议上讨论的。

结论

每 5 例死产中就有 2 例是由晚期 TOP 引起的,这表明现有的登记系统严重漏报,迫切需要适当的登记方法。尽管晚期 TOP 通常是由父母明确要求的,但在 1/4的情况下,终止妊娠是由医生首先建议的。父母有时不愿意主动提出晚期 TOP,这表明 TOP 应该始终被视为一种同等的选择进行咨询。

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