Shi Chunxia, Cao Pan, Wang Yukun, Zhang Qingqi, Zhang Danmei, Wang Yao, Wang Luwen, Gong Zuojiong
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
J Inflamm Res. 2023 Apr 12;16:1523-1532. doi: 10.2147/JIR.S403819. eCollection 2023.
PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.
全程序坏死性凋亡是Malireddi等人在2019年提出的一种新的细胞死亡方式，其特征是伴有细胞焦亡、凋亡和坏死性凋亡，但无法单独用其中任何一种来解释。细胞焦亡、凋亡和坏死性凋亡之间的相互作用参与了全程序坏死性凋亡。在这篇综述中，我们从全程序坏死性凋亡的角度，关注细胞焦亡、凋亡和坏死性凋亡之间的关系、全程序坏死性凋亡过程中的关键分子和全程序坏死小体的形成，以及全程序坏死性凋亡在疾病中的作用。我们旨在了解全程序坏死性凋亡的机制，并为靶向干预全程序坏死性凋亡相关分子以治疗人类疾病提供依据。
