Song Huapei, Liang Guangping, Wang Fengjun
Institute of Burn Research, The First Affiliated Hospital of Army Medical University (The Third Military Medical University), State Key Laboratory of Trauma and Chemical Poisoning, Gaotanyan Street, Shapingba Disdrict, Chongqing 400038, China.
Burns Trauma. 2025 Apr 10;13:tkaf026. doi: 10.1093/burnst/tkaf026. eCollection 2025.
Programmed cell death, which occurs via modes such as apoptosis, necroptosis, and pyroptosis, is an important mechanism for host defence against pathogens and inflammation-mediated immune responses. Recently, interactions between various types of cell death have gradually been discovered. PANoptosis is a newly discovered mode of programmed cell death that involves apoptosis, necroptosis, and pyroptosis and is closely related to many diseases. Ischaemia-reperfusion injury (IRI) is common in patients with blood circulation disorders such as those related to burns, traumatic shock, surgery, organ transplantation, and thrombus. However, the literature on the role of PANoptosis in IRI is limited. Herein, we systematically described the emergence of PANoptosis as a cell death mode, clinical evidence of its occurrence, the molecular mechanisms of PANoptosis, and its role in IRI. This study is expected to provide novel approaches for the prevention and treatment of tissue and organ IRI after severe burns.
程序性细胞死亡通过凋亡、坏死性凋亡和焦亡等方式发生，是宿主抵御病原体和炎症介导的免疫反应的重要机制。最近，已逐渐发现各种类型细胞死亡之间的相互作用。PANoptosis是一种新发现的程序性细胞死亡模式，涉及凋亡、坏死性凋亡和焦亡，并且与许多疾病密切相关。缺血再灌注损伤（IRI）在患有血液循环障碍的患者中很常见，例如与烧伤、创伤性休克、手术、器官移植和血栓相关的患者。然而，关于PANoptosis在IRI中的作用的文献有限。在此，我们系统地描述了PANoptosis作为一种细胞死亡模式的出现、其发生的临床证据、PANoptosis的分子机制及其在IRI中的作用。本研究有望为严重烧伤后组织和器官IRI的防治提供新方法。
