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某些儿科先天性和生长相关疾病中的端粒功能障碍。

Telomere dysfunction in some pediatric congenital and growth-related diseases.

作者信息

Zheng Bo, Fu Jianhua

机构信息

Department of Pediatrics, Sheng Jing Hospital of China Medical University, Shenyang, China.

出版信息

Front Pediatr. 2023 Apr 3;11:1133102. doi: 10.3389/fped.2023.1133102. eCollection 2023.

DOI:10.3389/fped.2023.1133102
PMID:37077333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10106694/
Abstract

Telomere wear and dysfunction may lead to aging-related diseases. Moreover, increasing evidence show that the occurrence, development, and prognosis of some pediatric diseases are also related to telomere dysfunction. In this review, we systematically analyzed the relationship between telomere biology and some pediatric congenital and growth-related diseases and proposed new theoretical basis and therapeutic targets for the treatment of these diseases.

摘要

端粒磨损和功能障碍可能导致与衰老相关的疾病。此外，越来越多的证据表明，一些儿科疾病的发生、发展和预后也与端粒功能障碍有关。在本综述中，我们系统地分析了端粒生物学与一些儿科先天性疾病和生长相关疾病之间的关系，并为这些疾病的治疗提出了新的理论基础和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/48b743e6f447/fped-11-1133102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/0a3a7259ab89/fped-11-1133102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/d298a93f6f53/fped-11-1133102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/3b8406693686/fped-11-1133102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/48b743e6f447/fped-11-1133102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/0a3a7259ab89/fped-11-1133102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/d298a93f6f53/fped-11-1133102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/3b8406693686/fped-11-1133102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/10106694/48b743e6f447/fped-11-1133102-g004.jpg

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Pediatr Res. 2023 Apr;93(5):1419-1424. doi: 10.1038/s41390-022-02255-w. Epub 2022 Aug 16.
2
Early life trauma and adult leucocyte telomere length.早期生活创伤与成人白细胞端粒长度。
Psychoneuroendocrinology. 2022 Oct;144:105876. doi: 10.1016/j.psyneuen.2022.105876. Epub 2022 Jul 23.
3
Association of Newborn Telomere Length With Blood Pressure in Childhood.
新生儿端粒长度与儿童期血压的关联。
JAMA Netw Open. 2022 Aug 1;5(8):e2225521. doi: 10.1001/jamanetworkopen.2022.25521.
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Telomerase reverse transcriptase (TERT) promotes neurogenesis after hypoxic-ischemic brain damage in neonatal rats.端粒酶逆转录酶（TERT）促进新生大鼠缺氧缺血性脑损伤后的神经发生。
Neurol Res. 2022 Sep;44(9):819-829. doi: 10.1080/01616412.2022.2056339. Epub 2022 Apr 10.
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Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.端粒长度不是 TEDDY 研究中胰岛自身免疫和 1 型糖尿病发展的主要因素。
Sci Rep. 2022 Mar 16;12(1):4516. doi: 10.1038/s41598-022-08058-7.
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