Liu Yang-Chen, Wu Bin, Wang Yan, Chen Song
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300070, China.
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin 300000, China.
Int J Ophthalmol. 2023 Apr 18;16(4):579-588. doi: 10.18240/ijo.2023.04.12. eCollection 2023.
To investigate the association of ganglion cell complex thickness (GCCt), global loss volume percentage (GLV%), and focal loss volume percentage (FLV%) with structural and functional findings among patients with chronic central serous chorioretinopathy (CCSC) and recurrent central serous chorioretinopathy (RCSC) by optical coherence tomography (OCT).
Among 29 patients with monocular affected central serous chorioretinopathy (CSC), 15 had CCSC, and 14 had RCSC. The GCCt, FLV%, GLV%, and subfoveal choroidal thickness (SFCT) and sublesional choroidal thickness (SLCT) values were determined using OCT, and the association of these characteristics with neural structure parameters, choroidal morphology, features and functional alterations were estimated for the CCSC and RCSC patients.
In CCSC, the affected eyes had significantly lower GCCt values than the fellow eyes in the macular regions (all <0.05), with the highest GCCt observed in the inferior area. A significant association was found between the GCCt in different regions and the change in best corrected visual acuity (BCVA; =-0.696; -0.695; -0.694, <0.05) in CCSC patients. A statistically significant moderate negative correlation indicated that long-term CCSC was associated with greater differences in the GCCt in different regions between affected and fellow eyes (=-0.562; =-0.556; =0.525, <0.05). Additionally, observation of thickened SFCT was associated with a worse FLV% (=0.599; =0.546, <0.05) in both groups. Similarly, thickened SLCT was associated with FLV% in RCSC patients (=0.544, <0.05).
The distribution and GCCt are associated with the duration and visual outcomes of CCSC, whereas there is no correlation among RCSC patients. FLV% may be instrumental in differentiating the various outer choroidal vessels (pachyvessels) in long-term CSC. These results suggest that neural structure parameters may aid in estimating and predicting the recovery of altered morphology and function in CCSC and RCSC patients.
通过光学相干断层扫描（OCT）研究慢性中心性浆液性脉络膜视网膜病变（CCSC）和复发性中心性浆液性脉络膜视网膜病变（RCSC）患者的神经节细胞复合体厚度（GCCt）、整体损失体积百分比（GLV%）和局灶性损失体积百分比（FLV%）与结构和功能结果之间的关联。
在29例单眼患中心性浆液性脉络膜视网膜病变（CSC）的患者中，15例为CCSC，14例为RCSC。使用OCT测定GCCt、FLV%、GLV%以及黄斑中心凹下脉络膜厚度（SFCT）和病变下脉络膜厚度（SLCT）值，并评估这些特征与CCSC和RCSC患者的神经结构参数、脉络膜形态、特征及功能改变之间的关联。
在CCSC中，患眼黄斑区的GCCt值显著低于对侧眼（均<0.05），在下象限观察到最高的GCCt。在CCSC患者中，不同区域的GCCt与最佳矫正视力（BCVA）的变化之间存在显著关联（=-0.696；=-0.695；=-0.694，<0.05）。具有统计学意义的中度负相关表明，长期CCSC与患眼和对侧眼不同区域GCCt的更大差异相关（=-0.562；=-0.556；=0.525，<0.05）。此外，两组中观察到SFCT增厚均与更差的FLV%相关（=0.599；=0.546，<0.05）。同样，RCSC患者中SLCT增厚与FLV%相关（=0.544，<0.05）。
GCCt的分布和厚度与CCSC的病程和视力结果相关，而RCSC患者之间无相关性。FLV%可能有助于区分长期CSC中各种外层脉络膜血管（厚血管）。这些结果表明，神经结构参数可能有助于评估和预测CCSC和RCSC患者形态和功能改变的恢复情况。
