Chrząszcz Michał, Pociej-Marciak Weronika, Żuber-Łaskawiec Katarzyna, Romanowska-Dixon Bożena, Sanak Marek, Michalska-Małecka Katarzyna, Petrovič Mojca Globočnik, Karska-Basta Izabella
Clinic of Ophthalmology and Ocular Oncology, Department of Ophthalmology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland.
Molecular Biology and Clinical Genetics Unit, Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland.
Medicina (Kaunas). 2021 Oct 5;57(10):1063. doi: 10.3390/medicina57101063.
Retinal pigment epitheliopathy and hyperpermeability of choroidal vessels were postulated to be involved in the pathogenesis of central serous chorioretinopathy (CSC). Imbalanced levels of vascular endothelial growth factor (VEGF) and pigment-epithelium-derived factor (PEDF) were previously implicated in the development of chorioretinal diseases characterized by increased vascular permeability. We aimed to compare the plasma levels of proangiogenic VEGF and antiangiogenic PEDF for 26 patients with acute CSC, 26 patients with chronic CSC, and 19 controls. VEGF and PEDF levels were measured using a multiplex immunoassay or enzyme-linked immunosorbent assay. Correlations with disease duration were assessed. VEGF levels differed between groups ( = 0.001). They were lower in patients with acute CSC ( = 0.042) and chronic CSC ( = 0.018) than in controls. PEDF levels were similar in all groups. The VEGF-to-PEDF ratio was lower in CSC patients than in controls ( = 0.04). A negative correlation with disease duration was noted only for PEDF levels in the group with chronic CSC (rho = -0.46, = 0.017). Our study confirmed that patients with CSC have imbalanced levels of VEGF and PEDF. This finding may have important implications for the pathogenesis of CSC. VEGF-independent arteriogenesis rather than angiogenesis may underlie vascular abnormalities in these patients.
视网膜色素上皮病变和脉络膜血管高通透性被认为与中心性浆液性脉络膜视网膜病变（CSC）的发病机制有关。血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）水平失衡先前被认为与以血管通透性增加为特征的脉络膜视网膜疾病的发生有关。我们旨在比较26例急性CSC患者、26例慢性CSC患者和19例对照者的促血管生成VEGF和抗血管生成PEDF的血浆水平。使用多重免疫测定或酶联免疫吸附测定法测量VEGF和PEDF水平。评估与病程的相关性。各组之间VEGF水平存在差异（=0.001）。急性CSC患者（=0.042）和慢性CSC患者（=0.018）的VEGF水平低于对照组。所有组的PEDF水平相似。CSC患者的VEGF与PEDF比值低于对照组（=0.04）。仅在慢性CSC组中观察到PEDF水平与病程呈负相关（rho=-0.46，=0.017）。我们的研究证实，CSC患者的VEGF和PEDF水平失衡。这一发现可能对CSC的发病机制具有重要意义。这些患者血管异常的基础可能是不依赖VEGF的动脉生成而非血管生成。
