Luo Yan-Hua, Xie Li, Li Jiao-Yang, Xie Yuan, Li Man-Qin, Zhou Li
Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Pediatric Medical Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Apr 12;16:1013-1020. doi: 10.2147/DMSO.S403934. eCollection 2023.
The increasing prevalence of obesity in children and its associated risk with cardiovascular diseases demand more discovery of the novel biomarkers for developing new treatment options for this complex disease. This study aimed to investigate the association of serum MOTS-C (a peptide encoded in the mitochondrial genome) levels and vascular endothelial function in obese children.
A total of 225 obese children (aged 8.1 ± 2.6 years) and 218 healthy children (aged 7.9 ± 2.2 years) were enrolled. Related anthropometric assessment and biochemical evaluation were done in all subjects. Reactive hyperemia index (RHI), as assessed by the peripheral arterial tonometry, was used for evaluation of peripheral endothelial function. Enzyme-linked immunosorbent assay (ELISA) was used to measure the level of serum MOTS-C.
Levels of serum MOTS-C and RHI were lower in the obese children compared with the healthy children ( < 0.01). The RHI level was independently associated with body mass index, high-density lipoprotein cholesterol, and MOTS-C in linear regression analysis. Further analysis showed a significant mediating effect of MOTS-C on the correlation between body mass index and RHI in children, with the ratio of mediating effect value of 9.12%.
These data identify that MOTS-C is a previously unknown regulator in the development process of obesity-induced vascular changes.
儿童肥胖患病率日益上升及其与心血管疾病相关的风险，需要更多地发现新型生物标志物，以开发针对这种复杂疾病的新治疗方案。本研究旨在探讨血清MOTS-C（一种线粒体基因组编码的肽）水平与肥胖儿童血管内皮功能之间的关联。
共纳入225名肥胖儿童（年龄8.1±2.6岁）和218名健康儿童（年龄7.9±2.2岁）。对所有受试者进行了相关人体测量评估和生化评估。通过外周动脉张力测量法评估的反应性充血指数（RHI）用于评估外周内皮功能。采用酶联免疫吸附测定（ELISA）法检测血清MOTS-C水平。
与健康儿童相比，肥胖儿童的血清MOTS-C水平和RHI较低（<0.01）。在线性回归分析中，RHI水平与体重指数、高密度脂蛋白胆固醇和MOTS-C独立相关。进一步分析显示，MOTS-C对儿童体重指数与RHI之间的相关性具有显著中介作用，中介效应值比例为9.12%。
这些数据表明，MOTS-C是肥胖诱导血管变化发展过程中一种此前未知的调节因子。
