Khan Imdad, Siraj Muhammad
Department of Biotechnology, University of Malakand, Pakistan.
Institute of Biotechnology and Genetic Engineering, University of Agriculture Peshawar, Pakistan.
Noncoding RNA Res. 2023 Mar 29;8(3):326-334. doi: 10.1016/j.ncrna.2023.03.007. eCollection 2023 Sep.
MicroRNAs (miRNAs) are small endogenous non-coding RNA, size range from 17 to 25 nucleotides that regulate gene expression at the post-transcriptional level. More than 2000 different types of miRNAs have been identified in humans which regulate about 60% of gene expression, since the discovery of the first miRNA in 1993. MicroRNA performs many functions such as being involved in the regulation of various biological pathways for example cell migration, cell proliferation, cell differentiation, disease progression, and initiation. miRNAs also play an important role in the development of atherosclerosis lesions, cardiac fibroblast, cardiac hypertrophy, cancer, and neurological disorders. Abnormal activation of many cell signaling pathways has been observed in the development of coronary artery disease. Abnormal expression of these candidate miRNA genes leads to up or downregulation of specific genes, these specific genes play an important role in the regulation of cell signaling pathways involved in coronary artery disease. Many studies have found that miRNAs play a key role in the regulation of crucial signaling pathways that are involved in the pathophysiology of coronary artery disease. This review is designed to investigate the role of cell signaling pathways regulated by candidate miRNAs in Coronary artery disease.
微小RNA（miRNA）是一类内源性非编码小RNA，长度在17至25个核苷酸之间，可在转录后水平调控基因表达。自1993年发现首个miRNA以来，已在人类中鉴定出2000多种不同类型的miRNA，它们调控着约60%的基因表达。微小RNA执行多种功能，例如参与各种生物途径的调控，如细胞迁移、细胞增殖、细胞分化、疾病进展和起始。miRNA在动脉粥样硬化病变、心脏成纤维细胞、心肌肥大、癌症和神经疾病的发展中也起着重要作用。在冠状动脉疾病的发展过程中，已观察到许多细胞信号通路的异常激活。这些候选miRNA基因的异常表达导致特定基因的上调或下调，这些特定基因在参与冠状动脉疾病的细胞信号通路调控中起重要作用。许多研究发现，miRNA在调控参与冠状动脉疾病病理生理学的关键信号通路中起关键作用。本综述旨在研究候选miRNA调控的细胞信号通路在冠状动脉疾病中的作用。
