Cotton B R, Henderson H P, Achola K J, Smith G
Br J Anaesth. 1986 Jun;58(6):593-7. doi: 10.1093/bja/58.6.593.
Plasma catecholamine concentrations have been measured in nine patients undergoing rhinoplasty following infiltration to the facial area of 21 ml of 0.5% lignocaine with adrenaline 1:200,000 and in seven patients undergoing brachial plexus blockade with 40 ml of 0.5% lignocaine, 0.25% bupivacaine and adrenaline 1:200,000. In the rhinoplasty group there was a 566% increase in plasma adrenaline concentration 2 min after cessation of infiltration, whilst in the brachial plexus group a 112% increase in the plasma concentration of adrenaline occurred at 10 min after completion of the block. There was no change in plasma noradrenaline concentration in either group. It is concluded that the so-called safe dose of adrenaline (1.0 microgram kg-1 during halothane anaesthesia) is meaningless unless the site of administration is specified.
对9例行鼻整形术的患者在面部浸润注射21毫升含1:200,000肾上腺素的0.5%利多卡因后，以及7例行臂丛神经阻滞的患者注射40毫升含1:200,000肾上腺素的0.5%利多卡因和0.25%布比卡因后，测定了血浆儿茶酚胺浓度。在鼻整形术组，浸润停止2分钟后血浆肾上腺素浓度增加了566%，而在臂丛神经阻滞组，阻滞完成10分钟后血浆肾上腺素浓度增加了112%。两组血浆去甲肾上腺素浓度均无变化。得出的结论是，除非指明给药部位，否则所谓的肾上腺素安全剂量（氟烷麻醉期间为1.0微克/千克）是没有意义的。
