Jain Ayushi, Alimirah Maryam, Hampel Heather, Pearlman Rachel, Ma Jianing, Peng Jing, Kalady Matthew F, Stanich Peter P
Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Front Oncol. 2022 Dec 20;12:1038678. doi: 10.3389/fonc.2022.1038678. eCollection 2022.
Lynch syndrome has not traditionally been considered to have a high colorectal adenoma burden. However, with increasing adenoma detection rates in the general population, the incidence of adenoma detection in Lynch syndrome may also be increasing and leading to higher cumulative adenoma counts.
To clarify the prevalence and clinical impact of multiple colorectal adenomas (MCRA) in Lynch syndrome.
A retrospective review of patients with Lynch syndrome at our institution was performed to assess for MCRA (defined as ≥10 cumulative adenomas).
There were 222 patients with Lynch syndrome among whom 14 (6.3%) met MCRA criteria. These patients had increased incidence of advanced neoplasia (OR 10, 95% CI: 2.7-66.7).
MCRA is not unusual in Lynch syndrome and is associated with a significantly increased likelihood of advanced colon neoplasia. Consideration should be given to differentiating colonoscopy intervals based on the presence of polyposis in Lynch syndrome.
传统上,林奇综合征未被认为具有高结直肠腺瘤负担。然而,随着普通人群腺瘤检出率的增加,林奇综合征中腺瘤的检出率可能也在上升,并导致累积腺瘤计数更高。
阐明林奇综合征中多发结直肠腺瘤(MCRA)的患病率及临床影响。
对本机构的林奇综合征患者进行回顾性研究,以评估MCRA(定义为累积腺瘤≥10个)。
共有222例林奇综合征患者,其中14例(6.3%)符合MCRA标准。这些患者进展期肿瘤的发生率增加(比值比10,95%置信区间:2.7 - 66.7)。
MCRA在林奇综合征中并不罕见,且与进展期结肠肿瘤的可能性显著增加相关。应考虑根据林奇综合征中息肉病的存在来区分结肠镜检查间隔时间。