Liu Hongyun, Liang Hui, Yu Xiaohua, Wang Guojing, Han Yi, Yan Muyang, Li Shijun, Wang Weidong
Research Center for Biomedical Engineering, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China.
Key Laboratory of Biomedical Engineering and Translational Medicine, Ministry of Industry and Information Technology, Beijing, China.
Front Physiol. 2023 Apr 3;14:1144073. doi: 10.3389/fphys.2023.1144073. eCollection 2023.
Accumulating evidence suggests that enhanced external counterpulsation (EECP) influences cardiac functions, hemodynamic characteristics and cerebral blood flow. However, little is known about whether or how the EECP affects the brain-heart coupling to produce these physiological and functional changes. We aimed to determine if the brain-heart coupling is altered during or after EECP intervention by assessing the heartbeat evoked potential (HEP) in healthy adults. Based on a random sham-controlled design, simultaneous electroencephalography and electrocardiography signals as well as blood pressure and flow status data were recorded before, during and after two consecutive 30-min EECP in 40 healthy adults (female/male: 17/23; age: 23.1 ± 2.3 years). HEP amplitude, frequency domain heart rate variability, electroencephalographic power and hemodynamic measurements of 21 subjects (female/male: 10/11; age: 22.7 ± 2.1 years) receiving active EECP were calculated and compared with those of 19 sham control subjects (female/male: 7/12; age: 23.6 ± 2.5 years). EECP intervention caused immediate obvious fluctuations of HEP from 100 to 400 ms after T-peak and increased HEP amplitudes in the (155-169) ms, (354-389) ms and (367-387) ms time windows after T-peak in the region of the frontal pole lobe. The modifications in HEP amplitude were not associated with changes in the analyzed significant physiological measurements and hemodynamic variables. Our study provides evidence that the HEP is modulated by immediate EECP stimuli. We speculate that the increased HEP induced by EECP may be a marker of enhanced brain-heart coupling. HEP may serve as a candidate biomarker for the effects and responsiveness to EECP.
越来越多的证据表明，增强型体外反搏（EECP）会影响心脏功能、血流动力学特征和脑血流量。然而，关于EECP是否以及如何影响脑心耦合以产生这些生理和功能变化，人们知之甚少。我们旨在通过评估健康成年人的心跳诱发电位（HEP）来确定在EECP干预期间或之后脑心耦合是否发生改变。基于随机假对照设计，在40名健康成年人（女性/男性：17/23；年龄：23.1±2.3岁）连续两次30分钟的EECP之前、期间和之后，记录同步脑电图和心电图信号以及血压和血流状态数据。计算了21名接受主动EECP的受试者（女性/男性：10/11；年龄：22.7±2.1岁）的HEP振幅、频域心率变异性、脑电图功率和血流动力学测量值，并与19名假对照受试者（女性/男性：7/12；年龄：23.6±2.5岁）进行比较。EECP干预导致T波峰值后100至400毫秒的HEP立即出现明显波动，并使额极叶区域T波峰值后（155 - 169）毫秒、（354 - 389）毫秒和（367 - 387）毫秒时间窗内的HEP振幅增加。HEP振幅的改变与分析的重要生理测量值和血流动力学变量的变化无关。我们的研究提供了证据表明HEP受到即时EECP刺激的调节。我们推测EECP诱导的HEP增加可能是脑心耦合增强的一个标志。HEP可能作为EECP效果和反应性的候选生物标志物。
