Shen Xueyang, Li Mingming, Shao Kangmei, Li Yongnan, Ge Zhaoming
Department of Neurology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Gansu Provincial Neurology Clinical Medical Research Center, The Second Hospital of Lanzhou University, Lanzhou, China.
Front Mol Neurosci. 2023 Apr 3;16:1076016. doi: 10.3389/fnmol.2023.1076016. eCollection 2023.
An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes cellular brain damage, inflammatory reaction, blood-brain barrier destruction, and nerve repair. During this process, the proportion and function of neurons, immune cells, glial cells, endothelial cells, and other cells change. Identifying potential differences in gene expression between cell types or heterogeneity between cells of the same type helps to understand the cellular changes that occur in the brain and the context of disease. The recent emergence of single-cell sequencing technology has promoted the exploration of single-cell diversity and the elucidation of the molecular mechanism of ischemic stroke, thus providing new ideas and directions for the diagnosis and clinical treatment of ischemic stroke.
当血管区域的血液供应受阻时，就会发生缺血性中风，导致神经细胞死亡并形成缺血核心。随后，大脑进入重建和修复阶段。整个过程包括细胞性脑损伤、炎症反应、血脑屏障破坏和神经修复。在此过程中，神经元、免疫细胞、神经胶质细胞、内皮细胞等细胞的比例和功能会发生变化。识别细胞类型之间基因表达的潜在差异或同一类型细胞之间的异质性，有助于了解大脑中发生的细胞变化以及疾病背景。单细胞测序技术的最新出现推动了对单细胞多样性的探索以及缺血性中风分子机制的阐明，从而为缺血性中风的诊断和临床治疗提供了新的思路和方向。
