Zhang Y, Chen M W J, Petersson F, Lim A A T
Discipline of Oral and Maxillofacial Surgery, National University Centre for Oral Health Singapore, Singapore; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore.
Department of Pathology, National University Hospital, Singapore.
Int J Oral Maxillofac Surg. 2023 Dec;52(12):1246-1249. doi: 10.1016/j.ijom.2023.03.014. Epub 2023 Apr 18.
Neurofibromas are frequently present in the skin, but are uncommon in the oral and maxillofacial region. There are three histological variants of neurofibroma: localized, diffuse, and plexiform. The plexiform histological variant of neurofibroma is the least common and is a rare occurrence in the oral cavity. Furthermore, plexiform neurofibroma is usually pathognomonic of neurofibromatosis type 1. A case of solitary plexiform neurofibroma of the tongue with no evidence of neurofibromatosis in a 50-year-old female Chinese patient is reported here. The lesion presented as a single, large, well-circumscribed rounded mass in the left hemi-tongue. The tumour was completely excised. No recurrence was observed at the 6-month follow-up.
神经纤维瘤常见于皮肤，但在口腔颌面部区域并不常见。神经纤维瘤有三种组织学变体：局限性、弥漫性和丛状。神经纤维瘤的丛状组织学变体最为少见，在口腔中极为罕见。此外，丛状神经纤维瘤通常是1型神经纤维瘤病的特征性表现。本文报告了一例50岁中国女性患者的孤立性舌丛状神经纤维瘤，无神经纤维瘤病证据。病变表现为左侧半舌的单个、大的、边界清晰的圆形肿物。肿瘤被完整切除。6个月随访未观察到复发。
