美泊利珠单抗成功治疗激素抵抗型嗜酸性粒细胞性胃肠病。
Successful Treatment of Steroid-resistant Eosinophilic Gastrointestinal Disease with Mepolizumab.
机构信息
Department of Gastroenterology, Juntendo University School of Medicine, Japan.
Department of Human Pathology, Juntendo University School of Medicine, Japan.
出版信息
Intern Med. 2023 Dec 1;62(23):3461-3467. doi: 10.2169/internalmedicine.0801-22. Epub 2023 Apr 21.
We experienced a case of treatment-resistant eosinophilic gastrointestinal disease (EGID). The patient, a 46-year-old man, presented with a fever, persistent abdominal pain, and an elevated peripheral eosinophil count. Eosinophil infiltration of the intestinal mucosa was also observed, and EGID was diagnosed. Corticosteroid therapy was initiated, but no improvement was seen. However, after mepolizumab (anti-interleukin 5 antibody) was administered, the patient's disease was controlled. Currently, the indications for mepolizumab are limited to bronchial asthma and paraneoplastic eosinophilic polyangiitis, but the experience herein reported suggests its usefulness in the treatment of EGID.
我们遇到了一例治疗抵抗性嗜酸性粒细胞性胃肠道疾病（EGID）。该患者为 46 岁男性，表现为发热、持续性腹痛和外周血嗜酸性粒细胞计数升高。还观察到肠黏膜嗜酸性粒细胞浸润，诊断为 EGID。开始使用皮质类固醇治疗，但未见改善。然而，给予美泊利珠单抗（抗白细胞介素 5 抗体）后，患者的疾病得到控制。目前，美泊利珠单抗的适应证仅限于支气管哮喘和副肿瘤性嗜酸性粒细胞性多血管炎，但本报告中的经验表明其在 EGID 治疗中的有用性。
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