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鼻骨和腭部原发性弥漫性大B细胞淋巴瘤:一种不寻常的临床表现。

Primary diffuse large B-cell lymphoma of the nasal bone and palate: An unusual clinical presentation.

作者信息

Abeles Elisabeth B, Umrau Kavita, Gray Mingyang L, Boahene Kofi D

机构信息

Department of Otolaryngology, Division of Facial Plastic and Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

出版信息

J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):572-575. doi: 10.4103/jomfp.jomfp_410_21. Epub 2022 Dec 22.

DOI:10.4103/jomfp.jomfp_410_21
PMID:37082085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10112089/
Abstract

Primary bone lymphomas account for 3-5% of extranodal non-Hodgkin lymphomas in adults and are typically present in the axial skeleton and weight-bearing bones. We present a unique case of primary bone diffuse large B-cell lymphoma (DLBCL) of the nasal bone and palate. We discuss the pathologic and radiologic findings and review the current literature and clinical management to highlight how this unusual clinical entity should be considered in differential diagnoses of head and neck bone masses.

摘要

原发性骨淋巴瘤占成人结外非霍奇金淋巴瘤的3% - 5%,通常发生于中轴骨骼和负重骨。我们报告一例罕见的鼻骨和腭部原发性骨弥漫性大B细胞淋巴瘤(DLBCL)病例。我们讨论其病理和影像学表现,并回顾当前文献及临床处理方法,以强调在头颈部骨肿块的鉴别诊断中应如何考虑这一特殊的临床实体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/172d9eba832c/JOMFP-26-572-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/73b923a4e89f/JOMFP-26-572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/894ac5483ad4/JOMFP-26-572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/7fed28a07deb/JOMFP-26-572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/f8ae41de2968/JOMFP-26-572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/172d9eba832c/JOMFP-26-572-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/73b923a4e89f/JOMFP-26-572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/894ac5483ad4/JOMFP-26-572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/7fed28a07deb/JOMFP-26-572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/f8ae41de2968/JOMFP-26-572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e13/10112089/172d9eba832c/JOMFP-26-572-g005.jpg

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本文引用的文献

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R-CHOP compared to R-CHOP + X for newly diagnosed diffuse large B-cell lymphoma: a systematic review and meta-analysis.利妥昔单抗联合环磷酰胺、多柔比星、长春新碱、泼尼松方案(R-CHOP)对比利妥昔单抗联合环磷酰胺、多柔比星、长春新碱、泼尼松方案联合 X 治疗初治弥漫性大 B 细胞淋巴瘤:一项系统评价和荟萃分析。
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The distinct clinical features and prognosis of the CD10⁺MUM1⁺ and CD10⁻Bcl6⁻MUM1⁻ diffuse large B-cell lymphoma.
CD10⁺MUM1⁺和CD10⁻Bcl6⁻MUM1⁻弥漫性大B细胞淋巴瘤的独特临床特征及预后
Sci Rep. 2016 Feb 9;6:20465. doi: 10.1038/srep20465.
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Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study).多灶性原发性骨淋巴瘤的临床特征、治疗和预后:国际结外淋巴瘤研究组(IELSG14 研究)的回顾性研究。
Br J Haematol. 2014 Mar;164(6):834-40. doi: 10.1111/bjh.12714. Epub 2014 Jan 2.
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