豚鼠肺灌注中血小板活化因子的过敏反应释放
The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.
作者信息
Fitzgerald M F, Moncada S, Parente L
出版信息
Br J Pharmacol. 1986 May;88(1):149-53. doi: 10.1111/j.1476-5381.1986.tb09481.x.
Abstract
The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.
摘要
研究了对照和致敏豚鼠离体肺在抗原刺激下血小板活化因子（血小板激活因子）及其无活性前体/代谢物溶血血小板激活因子（溶血血小板激活因子）的释放情况。通过肺循环或气道灌注并经抗原刺激的对照豚鼠肺未释放血小板激活因子。经肺循环灌注并经抗原刺激的致敏豚鼠离体肺释放了溶血血小板激活因子，但未释放血小板激活因子。经气道灌注并经抗原刺激的致敏豚鼠离体肺释放的溶血血小板激活因子多三倍，并且还释放了血小板激活因子。这些结果支持血小板激活因子在豚鼠呼吸道过敏反应中可能发挥的作用。
相似文献
1
The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.豚鼠肺灌注中血小板活化因子的过敏反应释放
Br J Pharmacol. 1986 May;88(1):149-53. doi: 10.1111/j.1476-5381.1986.tb09481.x.
2
The release of lyso-PAF from guinea-pig lungs.溶血血小板激活因子从豚鼠肺中的释放。
Eur J Pharmacol. 1985 Jun 7;112(2):281-4. doi: 10.1016/0014-2999(85)90511-4.
3
Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs.新型血小板活化因子拮抗剂WEB 2086对豚鼠支气管肺脏对血小板活化因子、主动及被动过敏反应性休克反应的干扰作用。
Eur J Pharmacol. 1987 Aug 21;140(3):311-21. doi: 10.1016/0014-2999(87)90288-3.
4
Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection.主动免疫可诱导豚鼠出现肺高反应性。加强注射的药理学调节及触发作用。
Am Rev Respir Dis. 1988 Dec;138(6):1572-8. doi: 10.1164/ajrccm/138.6.1572.
5
The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.血小板激活因子从豚鼠肺中释放血栓素A2不依赖血小板，其机制与白三烯不同。
Br J Pharmacol. 1984 Jul;82(3):565-75. doi: 10.1111/j.1476-5381.1984.tb10795.x.
6
Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists.血小板活化因子（PAF-乙酰醚）和变应原给药后嗜酸性粒细胞向豚鼠肺内的募集。前列环素、血小板耗竭及选择性拮抗剂的调节作用。
Am Rev Respir Dis. 1988 Apr;137(4):948-54. doi: 10.1164/ajrccm/137.4.948.
7
Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig.血小板活化因子拮抗剂BN 52021对豚鼠被动过敏反应的干扰作用。
Prostaglandins. 1987 Feb;33(2):265-74. doi: 10.1016/0090-6980(87)90011-6.
8
Role of lipoxygenase metabolites for the hyper-responsiveness to platelet-activating factor of lungs from actively sensitized guinea pigs.脂氧合酶代谢产物在主动致敏豚鼠肺脏对血小板活化因子高反应性中的作用。
J Pharmacol Exp Ther. 1989 Jan;248(1):353-9.
9
Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether.组胺和白三烯非依赖性豚鼠过敏性休克不能用血小板活化因子来解释。
Br J Pharmacol. 1985 Apr;84(4):801-10. doi: 10.1111/j.1476-5381.1985.tb17374.x.
10
Protection by two ginkgolides, BN-52020 and BN-52021, against guinea-pig lung anaphylaxis.两种银杏内酯BN - 52020和BN - 52021对豚鼠肺过敏反应的保护作用。
Pharmacol Res Commun. 1986 Sep;18(9):775-93. doi: 10.1016/0031-6989(86)90129-3.
引用本文的文献
1
Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2.豚鼠注射葡聚糖凝胶珠后早期支气管高反应性：血小板活化因子和血栓素A2的作用
Inflammation. 1999 Oct;23(5):437-48. doi: 10.1023/a:1021913009742.
2
Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea-pigs.麻醉豚鼠雾化激发诱导的支气管过敏反应的药理学调节
Br J Pharmacol. 1987 Jul;91(3):701-8. doi: 10.1111/j.1476-5381.1987.tb11265.x.
3
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对麻醉豚鼠支气管过敏反应的影响。
Br J Pharmacol. 1988 Jun;94(2):540-6. doi: 10.1111/j.1476-5381.1988.tb11558.x.
4
PAF antagonists. Their potential therapeutic role in asthma.血小板活化因子拮抗剂。它们在哮喘中的潜在治疗作用。
Drugs. 1988 Feb;35(2):93-103. doi: 10.2165/00003495-198835020-00001.
5
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.选择性血小板活化因子受体拮抗剂对豚鼠离体心脏中血小板活化因子诱导的血管收缩的拮抗作用。
Br J Pharmacol. 1987 Apr;90(4):771-83. doi: 10.1111/j.1476-5381.1987.tb11231.x.
6
Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs.特定血小板活化因子拮抗剂对主动致敏豚鼠肺脏对血小板活化因子自身高反应性的有限干扰。
Br J Pharmacol. 1989 Jun;97(2):433-42. doi: 10.1111/j.1476-5381.1989.tb11970.x.
7
Blockade by methylation inhibitors of the anaphylactic response of guinea-pig lung strips.甲基化抑制剂对豚鼠肺条过敏反应的阻断作用
Br J Pharmacol. 1987 Nov;92(3):683-91. doi: 10.1111/j.1476-5381.1987.tb11372.x.
8
Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.血小板活化因子气雾剂暴露诱导豚鼠肺气道嗜酸性粒细胞积聚：抗哮喘药物的作用
Br J Pharmacol. 1990 Feb;99(2):267-72. doi: 10.1111/j.1476-5381.1990.tb14692.x.
9
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.选择性PAF拮抗剂SM-10661对哮喘模型的作用。2. 对主动致敏清醒豚鼠抗原诱导的双重哮喘反应及白细胞向气道浸润的作用。
Lipids. 1991 Dec;26(12):1305-9. doi: 10.1007/BF02536554.
10
Platelet-activating factor in cardiovascular stress situations.心血管应激状态下的血小板活化因子
Lipids. 1991 Dec;26(12):1257-63. doi: 10.1007/BF02536543.
本文引用的文献
1
2
Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs. Pattern of response in relation to immunization regimen.主动致敏豚鼠中抗原诱导的支气管过敏反应。与免疫方案相关的反应模式。
Allergy. 1980 Jan;35(1):65-71. doi: 10.1111/j.1398-9995.1980.tb01718.x.
3
Nonimmunological production of leukotrienes induced by platelet-activating factor.血小板活化因子诱导的白三烯非免疫性产生
Science. 1982 Oct 15;218(4569):286-9. doi: 10.1126/science.7123233.
4
Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig.乙酰甘油醚磷酸胆碱（AGEPC）。豚鼠心脏过敏反应的一种假定介质。
Circ Res. 1984 Feb;54(2):117-24. doi: 10.1161/01.res.54.2.117.
5
Pressure effects and uptake of platelet-activating factor in isolated rat lung.压力对离体大鼠肺中血小板活化因子摄取的影响
J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct;57(4):1039-44. doi: 10.1152/jappl.1984.57.4.1039.
6
The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.血小板激活因子从豚鼠肺中释放血栓素A2不依赖血小板，其机制与白三烯不同。
Br J Pharmacol. 1984 Jul;82(3):565-75. doi: 10.1111/j.1476-5381.1984.tb10795.x.
7
8
9
Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages.血小板活化因子（PAF-乙醚）与巨噬细胞。II. 大鼠腹腔巨噬细胞吞噬作用相关的PAF-乙醚释放
Cell Immunol. 1981 Jan 15;57(2):281-92. doi: 10.1016/0008-8749(81)90087-3.
Zotero 插件