入住三级护理医院的高血压孕妇中潜在药物相互作用的发生率
Prevalence of Potential Drug-Drug Interactions Among Hypertensive Pregnant Women Admitted to a Tertiary Care Hospital.
作者信息
Ragam Akshitha S, S R Sheela
机构信息
Obstetrics and Gynaecology, Sri Devaraj Urs Medical College, Kolar, IND.
出版信息
Cureus. 2023 Mar 17;15(3):e36306. doi: 10.7759/cureus.36306. eCollection 2023 Mar.
AIMS AND OBJECTIVES
The aim is to determine the frequency of potential drug-drug interactions (pDDIs) and to analyze the clinically relevant drug interactions among hypertensive pregnant women.
MATERIALS AND METHODS
This was an observational, cross-sectional study conducted at a tertiary care hospital. The prescriptions of the hypertensive pregnant women admitted to the hospital from June 2021 to December 2021 were analyzed for potential drug-drug interactions using the database from Lexicomp ® Solutions android mobile application version 7.5.4 (Wolters Kluwer, The Netherlands).
RESULTS
A total of 127 patients were evaluated during the study period of 6 months, of which 70 (55.12%) had pDDIs. The total number of pDDIs was 85, of which 70 (82.35 %) were clinically relevant interactions with the majority of them having moderate severity (81.17%) followed by minor severity (17.65%) and major severity (1.18%). The most frequently interacting pDDIs were between Labetalol and Lornoxicam (42.35%), followed by Labetalol and Diclofenac (22.35%).
CONCLUSION
This study highlights the high prevalence of potential drug interactions among hypertensive pregnant women and the need for rational drug use and strict vigilance in their monitoring.
目的
确定潜在药物相互作用（pDDIs）的发生频率，并分析高血压孕妇中临床相关的药物相互作用。
材料与方法
这是一项在三级护理医院进行的观察性横断面研究。使用Lexicomp® Solutions安卓移动应用程序版本7.5.4（荷兰威科集团）的数据库，对2021年6月至2021年12月期间入院的高血压孕妇的处方进行潜在药物相互作用分析。
结果
在6个月的研究期间共评估了127例患者，其中70例（55.12%）存在pDDIs。pDDIs总数为85个，其中70个（82.35%）为临床相关相互作用，大多数为中度严重程度（81.17%），其次是轻度严重程度（17.65%）和重度严重程度（1.18%）。最常相互作用的pDDIs是拉贝洛尔与氯诺昔康之间（42.35%），其次是拉贝洛尔与双氯芬酸之间（22.35%）。
结论
本研究强调了高血压孕妇中潜在药物相互作用的高发生率，以及合理用药和严格监测的必要性。
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