Pessoa Thiago de Lima, Clemente Junior Washington Sales, Costa Tatiana Xavier da, Bezerra Priscilla Karilline do Vale, Martins Rand Randall
Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Einstein (Sao Paulo). 2019 May 30;17(3):eAO4521. doi: 10.31744/einstein_journal/2019AO4521.
To characterize severe potential drug interactions in maternal intensive care, and to determine their frequency, risk factors and potential risk medications.
An observational and longitudinal study conducted between December 2014 and December 2015 in a maternal intensive care unit. Clinical data were collected and severe potential drug interactions were identified on pregnant inpatients. The drug interactions were classified by type, prevalence and exposure rate. A multivariate logistic regression model was used to identify the severe potential drug interactions and the related drugs (p<0.05).
A total of 95.1% of patients were exposed to, at least, one potential drug interaction; in that, 91.7% 33.9% were related to, respectively, moderate and severe potential drug interactions. The patients were exposed, on average, on 69.2% of days they were in the intensive care unit. The main drugs involved in more severe drug interactions were magnesium sulfate, metoclopramide, propranolol and diazepam.
The severe potential drug interactions were observed in almost all patients of the study, and, approximately one third of those interactions were related to greater severity and resulted in exposure during long hospital stay. The higher number of prescribed drugs and its previous use of medications at home increase the occurrence of severe potential drug interactions.
描述孕产妇重症监护中严重的潜在药物相互作用，确定其发生频率、风险因素及潜在风险药物。
2014年12月至2015年12月在一家孕产妇重症监护病房进行的一项观察性纵向研究。收集临床数据，识别住院孕妇中的严重潜在药物相互作用。根据类型、患病率和暴露率对药物相互作用进行分类。使用多因素逻辑回归模型识别严重潜在药物相互作用及相关药物（p<0.05）。
共有95.1%的患者至少暴露于一种潜在药物相互作用；其中，分别有91.7%和33.9%与中度和严重潜在药物相互作用有关。患者在重症监护病房期间平均有69.2%的天数暴露于药物相互作用。参与更严重药物相互作用的主要药物有硫酸镁、甲氧氯普胺、普萘洛尔和地西泮。
本研究几乎所有患者均观察到严重潜在药物相互作用，其中约三分之一的相互作用与更高的严重程度有关，并导致患者在长时间住院期间暴露。处方药物数量较多及其在家中曾使用过药物会增加严重潜在药物相互作用的发生。
