Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Department of Neurology, MS Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Dement Geriatr Cogn Disord. 2018;46(1-2):60-80. doi: 10.1159/000491818. Epub 2018 Aug 24.
BACKGROUND/AIMS: There is no consensus regarding the optimal nonpharmacological intervention to slow down dementia-related decline. We examined whether physical stimulation interventions were effective in reducing cognitive, physical, mood, and behavioral decline in nursing home residents with dementia.
Eighty-seven nursing home residents with dementia were randomly assigned to 3 physical activity interventions: activities of daily living (ADL) training, multicomponent exercise training, or combined multicomponent exercise and ADL training. Outcomes were measured at baseline, and after 3 and 6 months.
A 6-month ADL training benefitted executive functions, physical endurance, and depression among men. Exercise training benefitted only grip strength of participants with mild-to-moderate cognitive impairment. A combined training benefitted functional mobility compared to ADL training, depressive symptoms and agitation compared to exercise training, and physical endurance compared to no physical stimulation.
ADL training appears to be effective for nursing home residents with moderately severe dementia. It remains unclear whether exercise training is an effective type of stimulation.
背景/目的：目前对于哪种非药物干预措施最能减缓与痴呆相关的衰退，尚未达成共识。我们旨在研究身体刺激干预措施是否能有效减缓养老院痴呆患者的认知、身体、情绪和行为下降。
87 名养老院痴呆患者被随机分配到 3 种身体活动干预组中：日常生活活动（ADL）训练、多组分运动训练或组合式多组分运动和 ADL 训练。在基线、3 个月和 6 个月时进行了评估。
6 个月的 ADL 训练有益于男性的执行功能、身体耐力和抑郁。运动训练仅有益于认知障碍轻度至中度患者的握力。与 ADL 训练相比，组合训练更有益于功能性移动能力，与运动训练相比，更有益于抑郁症状和激越，与无身体刺激相比，更有益于身体耐力。
ADL 训练似乎对中度严重痴呆的养老院居民有效。运动训练是否是一种有效的刺激方式仍不清楚。
