Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, P.R. China.
HKUST Shenzhen Research Institute, No. 9 Yuexing 1st Road, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China.
Macromol Rapid Commun. 2023 Jul;44(13):e2300104. doi: 10.1002/marc.202300104. Epub 2023 May 5.
Recent advancements in aggregation-induced emission (AIE) macromolecular materials have brought their attention as potential antibacterial solutions, these materials offer new approaches to cure multidrug-resistant infections and biofilms in bacterial infections as well as real-time monitoring and specific targeting of bacteria. This review provides an overview of the three main categories of AIE macromolecular materials with antibacterial properties; namely AIE-active polymers, AIEgen@polymer complexes, and clusterization-triggered emission (CTE) based polymers. The mechanisms and applications of these materials in antibacterial treatment, wound care, and protective equipment are also discussed. The potential for future developments and application directions of AIE-based antimicrobial materials are finally highlighted.
近年来,聚集诱导发光(AIE)高分子材料的发展引起了人们的关注,它们有望成为潜在的抗菌解决方案。这些材料为治疗多重耐药感染和细菌感染中的生物膜提供了新的方法,并且可以实时监测和特异性靶向细菌。本文综述了具有抗菌性能的三种主要 AIE 高分子材料,即 AIE 活性聚合物、AIEgen@聚合物复合物和基于聚集诱导发光的聚合物。还讨论了这些材料在抗菌治疗、伤口护理和防护设备中的应用。最后,强调了基于 AIE 的抗菌材料的未来发展潜力和应用方向。