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含聚集诱导发光剂的抗菌抗微生物肽接枝透明质酸/丝素蛋白/海藻酸钠伤口敷料用于感染伤口治疗

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating.

作者信息

Lin Yize, Tan Yan, Deng Rong, Gong Li, Feng Xiaoshan, Cai Zhongqi, He Yanxian, Feng Longbao, Cheng Biao, Chen Yi

机构信息

Graduate School, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, P. R. China.

Department of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.

出版信息

ACS Omega. 2024 May 21;9(22):23499-23511. doi: 10.1021/acsomega.4c00649. eCollection 2024 Jun 4.

DOI:10.1021/acsomega.4c00649
PMID:38854545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11154921/
Abstract

Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial and powerful wound microenvironment regulation and protection function to promote wounds heal quickly. In this study, a multifunctional composite dressing (HA-AMP/SF/Alg/Rb-BG-AIEgens) was synthesized by combining a mesoporous bioactive glass framework loaded with AIEgens (Rb-BG-AIEgens) with cross-linked antimicrobial peptide grafted hyaluronic acid (HA-AMP), sodium alginate (Alg), and silk fibroin (SF). It is important to note that the Rb-BG-AIEgens can achieve real-time and sensitive bacterial detection. HA-AMP can achieve broad spectrum antibacterial and avoid the residue of drug-resistant bacteria. The HA-AMP/SF/Alg/Rb-BG-AIEgens dressing can up-regulate related proliferative proteins, thereby promoting regeneration of tissue and the rapid healing of chronic wounds. With good biocompatibility and antibacterial ability, HA-AMP/SF/Alg/Rb-BG-AIEgens dressing has great potential to become a next generation wound dressing for clinical biological fluid management and chronic bacterial infection treatment.

摘要

慢性伤口的特征是生物流体过多且持续感染。因此，迫切需要开发一种多功能伤口敷料，以满足包括有效抗菌、强大的伤口微环境调节和保护功能等极端要求，从而促进伤口快速愈合。在本研究中，通过将负载聚集诱导发光剂（Rb-BG-AIEgens）的介孔生物活性玻璃框架与交联抗菌肽接枝透明质酸（HA-AMP）、海藻酸钠（Alg）和丝素蛋白（SF）相结合，合成了一种多功能复合敷料（HA-AMP/SF/Alg/Rb-BG-AIEgens）。需要注意的是，Rb-BG-AIEgens可以实现实时且灵敏的细菌检测。HA-AMP可以实现广谱抗菌并避免耐药菌残留。HA-AMP/SF/Alg/Rb-BG-AIEgens敷料可以上调相关增殖蛋白，从而促进组织再生和慢性伤口的快速愈合。具有良好的生物相容性和抗菌能力，HA-AMP/SF/Alg/Rb-BG-AIEgens敷料极有潜力成为用于临床生物流体管理和慢性细菌感染治疗的下一代伤口敷料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/1b868e55447e/ao4c00649_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/f0fb090d2905/ao4c00649_0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/1b868e55447e/ao4c00649_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/f0fb090d2905/ao4c00649_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/e2f2c879e7fa/ao4c00649_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/8e4191612c6f/ao4c00649_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/e6fde276af62/ao4c00649_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/0d723c864bd7/ao4c00649_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/507ba1778533/ao4c00649_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc0e/11154921/1b868e55447e/ao4c00649_0008.jpg

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本文引用的文献

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J Biomater Sci Polym Ed. 2024 Feb;35(3):397-414. doi: 10.1080/09205063.2023.2289247. Epub 2024 Feb 1.
2
Aggregation-Induced Emission Macromolecular Materials for Antibacterial Applications.用于抗菌应用的聚集诱导发光高分子材料。
Macromol Rapid Commun. 2023 Jul;44(13):e2300104. doi: 10.1002/marc.202300104. Epub 2023 May 5.
3
Antimicrobial peptides for combating drug-resistant bacterial infections.
用于对抗耐药细菌感染的抗菌肽。
Drug Resist Updat. 2023 May;68:100954. doi: 10.1016/j.drup.2023.100954. Epub 2023 Mar 1.
4
Design and evaluation of sodium alginate-based hydrogel dressings containing Betula utilis extract for cutaneous wound healing.含桦木提取物的海藻酸钠基水凝胶敷料用于皮肤伤口愈合的设计与评价
Front Bioeng Biotechnol. 2023 Jan 26;11:1042077. doi: 10.3389/fbioe.2023.1042077. eCollection 2023.
5
Construction of porous structure-based carboxymethyl chitosan/ sodium alginate/ tea polyphenols for wound dressing.基于多孔结构的羧甲基壳聚糖/海藻酸钠/茶多酚用于伤口敷料的构建。
Int J Biol Macromol. 2023 Apr 1;233:123404. doi: 10.1016/j.ijbiomac.2023.123404. Epub 2023 Jan 24.
6
Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.具有缓解内质网应激特性的益生菌功能化丝素/海藻酸钠支架促进无痕伤口愈合
ACS Appl Mater Interfaces. 2023 Feb 8;15(5):6297-6311. doi: 10.1021/acsami.2c17168. Epub 2023 Jan 26.
7
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition.人脐带间充质干细胞来源的外泌体通过促进 M2 巨噬细胞极化、血管生成和胶原沉积加速糖尿病创面愈合。
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8
Mechanical Force Induced Self-Assembly of Chinese Herbal Hydrogel with Synergistic Effects of Antibacterial Activity and Immune Regulation for Wound Healing.机械力诱导的具有抗菌活性和免疫调节协同作用的用于伤口愈合的中药水凝胶自组装
Small. 2022 May;18(21):e2201766. doi: 10.1002/smll.202201766. Epub 2022 May 1.
9
Strategies for improving antimicrobial peptide production.提高抗菌肽生产的策略。
Biotechnol Adv. 2022 Oct;59:107968. doi: 10.1016/j.biotechadv.2022.107968. Epub 2022 Apr 28.
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