• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以靶向泛素化修饰作为一种新的肺癌治疗方法（综述）。

Targeting neddylation as a novel approach to lung cancer treatment (Review).

机构信息

Science and Technology Innovation Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250117, P.R. China.

School of Clinical and Basic Medical Sciences, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250117, P.R. China.

出版信息

Int J Oncol. 2023 May;62(5). doi: 10.3892/ijo.2023.5513. Epub 2023 Apr 21.

DOI:10.3892/ijo.2023.5513
PMID:37083098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10147314/
Abstract

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.

摘要

作为一种类似于泛素的蛋白质，神经前体细胞表达发育下调蛋白 8（NEDD8）参与了类泛素化修饰，这种修饰方式与泛素化相似，可以改变靶蛋白的活性。Neddylation 可能影响多种信号通路的活性，在肿瘤的发生、发展和转移中具有调节作用，并影响癌症治疗的预后。本文综述了 NEDD8 在 MDM2-p53、NF-κB、PI3K/AKT/mTOR、缺氧诱导因子、Hippo 和受体酪氨酸激酶信号通路中的调节作用，以及在肺癌发生和发展中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/7163256841a9/IJO-62-5-05513-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/6e80425764a8/IJO-62-5-05513-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/1396daf3ae78/IJO-62-5-05513-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/35cde8254783/IJO-62-5-05513-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/d29f68e113d1/IJO-62-5-05513-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/7163256841a9/IJO-62-5-05513-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/6e80425764a8/IJO-62-5-05513-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/1396daf3ae78/IJO-62-5-05513-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/35cde8254783/IJO-62-5-05513-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/d29f68e113d1/IJO-62-5-05513-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee5/10147314/7163256841a9/IJO-62-5-05513-g04.jpg

相似文献

1
Targeting neddylation as a novel approach to lung cancer treatment (Review).以靶向泛素化修饰作为一种新的肺癌治疗方法（综述）。
Int J Oncol. 2023 May;62(5). doi: 10.3892/ijo.2023.5513. Epub 2023 Apr 21.
2
Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.验证 NEDD8 连接酶 UBC12 作为肺癌的一个新治疗靶点。
EBioMedicine. 2019 Jul;45:81-91. doi: 10.1016/j.ebiom.2019.06.005. Epub 2019 Jun 14.
3
Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).结直肠癌研究进展：揭示泛素化修饰的细胞和分子机制（综述）。
Int J Oncol. 2024 Apr;64(4). doi: 10.3892/ijo.2024.5627. Epub 2024 Feb 23.
4
Overactivated neddylation pathway as a therapeutic target in lung cancer.过度激活的 neddylation 通路作为肺癌的治疗靶点。
J Natl Cancer Inst. 2014 May 22;106(6):dju083. doi: 10.1093/jnci/dju083. Print 2014 Jun.
5
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.靶向泛素样修饰物 NEDD8 治疗肺腺癌。
Cell Biol Toxicol. 2020 Aug;36(4):349-364. doi: 10.1007/s10565-019-09503-6. Epub 2020 Jan 6.
6
Diverse and pivotal roles of neddylation in metabolism and immunity.Neddylation在代谢和免疫中的多样关键作用。
FEBS J. 2021 Jul;288(13):3884-3912. doi: 10.1111/febs.15584. Epub 2020 Oct 20.
7
Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells.抑制 neddylation 通过增强 PC3 和 U373MG 细胞中 cavlin-1 的磷酸化促进细胞迁移。
BMC Cancer. 2018 Jan 5;18(1):30. doi: 10.1186/s12885-017-3942-9.
8
DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage.DYRK2 通过对 DNA 损伤的反应来维持基因组稳定性，通过 cullins 的 neddylation 来实现。
J Cell Sci. 2022 Jun 1;135(11). doi: 10.1242/jcs.259514. Epub 2022 Jun 8.
9
Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.MLN4924 通过抑制 neddylation 修饰增强肝癌细胞对索拉非尼的敏感性。
Oncol Rep. 2019 Jun;41(6):3257-3269. doi: 10.3892/or.2019.7098. Epub 2019 Apr 4.
10
Neddylation Inactivation Facilitates FOXO3a Nuclear Export to Suppress Estrogen Receptor Transcription and Improve Fulvestrant Sensitivity.泛素化失活促进 FOXO3a 的核输出，抑制雌激素受体转录，提高氟维司群敏感性。
Clin Cancer Res. 2019 Jun 15;25(12):3658-3672. doi: 10.1158/1078-0432.CCR-18-2434. Epub 2019 Mar 4.

引用本文的文献

1
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis.Neddylation对神经母细胞瘤免疫微环境中预后的影响：一项单细胞转录组分析
Immunol Res. 2025 Jul 17;73(1):107. doi: 10.1007/s12026-025-09662-1.
2
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin.Neddylation修饰通过拮抗LC3B的泛素介导降解并促进皮肤自噬来使其稳定。
Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e2411429122. doi: 10.1073/pnas.2411429122. Epub 2025 Apr 10.

本文引用的文献

1
Integrative Serum Metabolic Fingerprints Based Multi-Modal Platforms for Lung Adenocarcinoma Early Detection and Pulmonary Nodule Classification.基于整合血清代谢指纹的多模态平台用于肺腺癌早期检测和肺结节分类。
Adv Sci (Weinh). 2022 Dec;9(34):e2203786. doi: 10.1002/advs.202203786. Epub 2022 Oct 18.
2
Defective Fe Metal-Organic Frameworks Enhance Metabolic Profiling for High-Accuracy Diagnosis of Human Cancers.缺陷型 Fe 金属有机框架增强代谢组学分析，实现人类癌症的高精度诊断。
Adv Mater. 2022 Jul;34(26):e2201422. doi: 10.1002/adma.202201422. Epub 2022 May 23.
3
A Versatile Electrochemical Biosensor for the Detection of Circulating MicroRNA toward Non-Small Cell Lung Cancer Diagnosis.
一种用于检测非小细胞肺癌的循环 microRNA 的多功能电化学生物传感器。
Small. 2022 Jun;18(22):e2200784. doi: 10.1002/smll.202200784. Epub 2022 Mar 25.
4
TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy.TGFβ 受体抑制作用释放肿瘤相关巨噬细胞中的干扰素-β产生并增强放射治疗效果。
J Immunother Cancer. 2022 Mar;10(3). doi: 10.1136/jitc-2021-003519.
5
Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy.发现一种触发内质网应激以诱导自噬的cullin类泛素化小分子抑制剂。
Acta Pharm Sin B. 2021 Nov;11(11):3567-3584. doi: 10.1016/j.apsb.2021.07.012. Epub 2021 Jul 17.
6
NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis.NEDD8 连接酶 E2 UBE2F 通过保护肺癌细胞免于凋亡赋予其辐射抗性。
J Zhejiang Univ Sci B. 2021 Nov 15;22(11):959-965. doi: 10.1631/jzus.B2100170.
7
A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).一种用于肝癌光热治疗的聚多巴胺纳米药物可抑制抑癌靶点 NEDD8-E3 连接酶 ROC1（RBX1）。
J Nanobiotechnology. 2021 Oct 15;19(1):323. doi: 10.1186/s12951-021-01063-4.
8
Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.合成致死筛选揭示结直肠癌对NEDD8和EGFR通路联合阻断的易感性。
Cancers (Basel). 2021 Jul 28;13(15):3805. doi: 10.3390/cancers13153805.
9
Lung cancer.肺癌。
Lancet. 2021 Aug 7;398(10299):535-554. doi: 10.1016/S0140-6736(21)00312-3. Epub 2021 Jul 21.
10
PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer.PI3K/Akt/mTOR 信号通路调控小细胞肺癌的表型转化和化疗耐药。
J Genet Genomics. 2021 Jul 20;48(7):640-651. doi: 10.1016/j.jgg.2021.04.001. Epub 2021 Apr 27.