Videen T O, Daw N W, Collins R C
Brain Res. 1986 Apr 16;371(1):1-8. doi: 10.1016/0006-8993(86)90803-6.
Epileptiform activity was induced in the visual cortex with penicillin to test whether it would prevent the ocular dominance shift that normally occurs in monocularly deprived kittens. The eyelids of one eye of 5-week-old kittens were sutured shut for several days. During this period, whenever the kittens were in the light, aqueous penicillin in artificial cerebrospinal fluid (CSF) or just CSF was applied in a cylinder mounted over the visual cortex. Electroencephalograms monitored during the period of deprivation indicated nearly continuous interictal spiking in the visual cortex. Extracellular recordings were made of cells in the region directly under the position of the cylinder. 14C-labeled 2-deoxyglucose autoradiography in a control kitten showed that this area had considerably increased metabolism during epileptiform activity. The majority of cortical cells were dominated by the non-deprived eye in both epileptic and control kittens, with no noticeable difference between them. These preliminary observations indicate that the disruption of cortical activity that occurs during interictal epileptiform activity does not prevent the ocular dominance shift in monocularly deprived kittens.
用青霉素在视觉皮层诱导癫痫样活动，以测试其是否会阻止单眼剥夺小猫中正常发生的眼优势转移。将5周龄小猫的一只眼睛的眼睑缝合几天。在此期间，每当小猫处于光照下时，将含青霉素的人工脑脊液（CSF）或仅CSF注入安装在视觉皮层上方的圆柱体中。剥夺期间监测的脑电图显示视觉皮层几乎持续出现发作间期棘波。在圆柱体位置正下方的区域对细胞进行细胞外记录。对一只对照小猫进行的14C标记的2-脱氧葡萄糖放射自显影显示，该区域在癫痫样活动期间代谢显著增加。在癫痫小猫和对照小猫中，大多数皮层细胞都由未被剥夺的眼睛支配，两者之间没有明显差异。这些初步观察结果表明，发作间期癫痫样活动期间发生的皮层活动中断并不能阻止单眼剥夺小猫的眼优势转移。
