发育中的视觉皮层中局部GABA环路对经验依赖性可塑性的控制
Local GABA circuit control of experience-dependent plasticity in developing visual cortex.
作者信息
Hensch T K, Fagiolini M, Mataga N, Stryker M P, Baekkeskov S, Kash S F
机构信息
Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
出版信息
Science. 1998 Nov 20;282(5393):1504-8. doi: 10.1126/science.282.5393.1504.
Abstract
Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.
摘要
早期生活中的感觉体验塑造了哺乳动物的大脑。在此，我们在一个小鼠模型中发现了发育中的视觉皮层内功能连接的活动依赖性精细化受损。谷氨酸脱羧酶一种同工型的基因靶向破坏阻止了对短暂剥夺视力的眼睛反应性的竞争性丧失，而不影响体外突触修饰的协同机制。用苯二氮䓬类药物选择性地、依赖使用增强快速皮质内抑制性传递可恢复体内可塑性，挽救遗传缺陷。视觉皮层固有的抑制性中间神经元的特定网络可能检测感觉输入中的扰动，以驱动发育过程中依赖经验的可塑性。
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本文引用的文献
1
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE.单眼视觉剥夺小猫纹状皮层的单细胞反应
J Neurophysiol. 1963 Nov;26:1003-17. doi: 10.1152/jn.1963.26.6.1003.
2
BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses.脑源性神经营养因子对锥体神经元和中间神经元兴奋性突触的量子幅度具有相反的作用。
Neuron. 1998 Sep;21(3):521-30. doi: 10.1016/s0896-6273(00)80563-2.
3
Nerve growth factor and brain-derived neurotrophic factor increase neurotransmitter release in the rat visual cortex.神经生长因子和脑源性神经营养因子可增加大鼠视皮层中的神经递质释放。
Eur J Neurosci. 1998 Jun;10(6):2185-91. doi: 10.1046/j.1460-9568.1998.00227.x.
4
Noradrenergic excitation and inhibition of GABAergic cell types in rat frontal cortex.去甲肾上腺素能对大鼠额叶皮质中γ-氨基丁酸能细胞类型的兴奋和抑制作用
J Neurosci. 1998 Sep 1;18(17):6963-76. doi: 10.1523/JNEUROSCI.18-17-06963.1998.
5
Cholinergic switching within neocortical inhibitory networks.新皮质抑制性网络中的胆碱能转换
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6
How many subtypes of inhibitory cells in the hippocampus?海马体中抑制性细胞有多少种亚型？
Neuron. 1998 May;20(5):983-93. doi: 10.1016/s0896-6273(00)80479-1.
7
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J Comp Neurol. 1998 Jun 1;395(2):177-94. doi: 10.1002/(sici)1096-9861(19980601)395:2<177::aid-cne3>3.0.co;2-#.
8
From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.从GABAA受体的多样性中浮现出对γ-氨基丁酸能抑制作用的统一认识。
Annu Rev Pharmacol Toxicol. 1998;38:321-50. doi: 10.1146/annurev.pharmtox.38.1.321.
9
Differentially interconnected networks of GABAergic interneurons in the visual cortex of the cat.猫视觉皮层中γ-氨基丁酸能中间神经元的差异互连网络。
J Neurosci. 1998 Jun 1;18(11):4255-70. doi: 10.1523/JNEUROSCI.18-11-04255.1998.
10
GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex.大鼠视觉皮层中间神经元和锥体细胞中GABAA受体介导的电流
J Physiol. 1998 Feb 1;506 ( Pt 3)(Pt 3):715-30. doi: 10.1111/j.1469-7793.1998.715bv.x.
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