Daszuta A, Faudon M, Hery F
Brain Res Bull. 1984 May;12(5):565-70. doi: 10.1016/0361-9230(84)90173-4.
"In vitro" 3H-5-HT and 3H-5-HIAA, newly synthesized from 3H-TRP, are measured in the brainstem, the anterior raphe nuclei and the locus coeruleus of C57BL and BALBc mice. As found for the caudate nucleus and the hippocampus, higher synthesis and release are determined in C57BL than in BALBc, for the locus coeruleus and more globally, for the brainstem. But these differences disappear when the study is carried on the raphe dorsalis and the raphe centralis nuclei. Therefore the serotonergic activity could be independently regulated at the level of cell bodies and at those of terminals. However, the 5-HT metabolism of NRD of BALBc mice could be submitted to a specific autoinhibition which could explain a lower 5-HT synthesis and release at the corresponding terminal level, compared to C57BL.
从3H-色氨酸新合成的“体外”3H-5-羟色胺（3H-5-HT）和3H-5-羟吲哚乙酸（3H-5-HIAA）在C57BL和BALBc小鼠的脑干、中缝前核和蓝斑中进行测量。正如在尾状核和海马体中所发现的那样，对于蓝斑以及更广泛地对于脑干，C57BL小鼠中的合成和释放高于BALBc小鼠。但是当研究在背侧中缝核和中央中缝核上进行时，这些差异消失了。因此，5-羟色胺能活性可能在细胞体水平和终末水平上受到独立调节。然而，BALBc小鼠中缝背核（NRD）的5-羟色胺代谢可能受到一种特定的自身抑制作用，这可以解释与C57BL小鼠相比，在相应终末水平上5-羟色胺的合成和释放较低的原因。
