Fortenbach Christopher R, Whitmore S Scott, Thurtell Matthew J, Sohn Elliott H, Critser D Brice, Stone Edwin M, Folk James C, Han Ian C, Boyce Timothy M
Department of Ophthalmology and Visual Sciences, The University of Iowa Institute for Vision Research, Iowa City, Iowa, USA.
Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Ocul Immunol Inflamm. 2024 Jul;32(5):727-734. doi: 10.1080/09273948.2023.2199334. Epub 2023 Apr 21.
Autoimmune retinopathy (AIR) is a poorly characterized disease with a wide phenotypic spectrum, complicating investigations of its underlying pathophysiology. We sought to analyze optical coherence tomography (OCT) retinal thickness changes in AIR patients.
A retrospective chart review from 2007 to 2017 was performed evaluating AIR patients at a single academic, tertiary referral center. OCT retinal sublayer analysis was performed, and paradoxical thickening phenotypes were reviewed.
Twenty-nine AIR patients with positive anti-retinal antibodies and OCT imaging were identified. Overall, AIR patients had thinner retinal sublayers compared to controls; however, 12 patients (41.4%) had paradoxical thickening of the outer plexiform layer (OPL). This revealed two distinct OCT phenotypes. No association was found between retinal sublayer thickness and specific antiretinal antibodies.
While the pathogenicity of antiretinal antibodies remains unclear, the OCT phenotypes observed underscore the potential for identifying clues in the underlying disease processes and clinical diagnosis.
自身免疫性视网膜病（AIR）是一种特征描述不清的疾病，其表型范围广泛，这使其潜在病理生理学研究变得复杂。我们试图分析AIR患者的光学相干断层扫描（OCT）视网膜厚度变化。
对2007年至2017年期间在一家单一的学术性三级转诊中心接受评估的AIR患者进行回顾性病历审查。进行了OCT视网膜子层分析，并对矛盾性增厚表型进行了审查。
确定了29例抗视网膜抗体阳性且有OCT成像的AIR患者。总体而言，与对照组相比，AIR患者的视网膜子层更薄；然而，12例患者（41.4%）的外丛状层（OPL）出现矛盾性增厚。这揭示了两种不同的OCT表型。未发现视网膜子层厚度与特定抗视网膜抗体之间存在关联。
虽然抗视网膜抗体的致病性仍不清楚，但观察到的OCT表型强调了在潜在疾病过程和临床诊断中识别线索的可能性。
