Wood P L
Can J Physiol Pharmacol. 1986 Mar;64(3):325-8. doi: 10.1139/y86-053.
The presence of different receptor populations within a given brain area can be effectively evaluated via the local injections of defined receptor agonists and antagonists. Using this approach, it has become evident that the nucleus basalis - cortical cholinergic pathway possesses an inhibitory GABAergic input to the nucleus basalis from the nucleus accumbens as well as a positive glutamatergic feedback from the cortex. The septal-hippocampal cholinergic pathway also possesses an inhibitory GABAergic regulation which consists of a large GABAergic interneuron population in the septum. A glutamatergic feedback from the hippocampus is also present. These regulatory inputs to cholinergic cells are not tonically active but appear to function as phasic modulators of cholinergic transmission in both pathways.
通过在特定脑区局部注射特定的受体激动剂和拮抗剂，可以有效地评估给定脑区内不同受体群体的存在情况。采用这种方法，现已明确，基底核-皮质胆碱能通路具有来自伏隔核到基底核的抑制性GABA能输入，以及来自皮质的兴奋性谷氨酸能反馈。隔区-海马胆碱能通路也具有抑制性GABA能调节，该调节由隔区内大量的GABA能中间神经元群体组成。海马也存在谷氨酸能反馈。这些对胆碱能细胞的调节性输入并非持续活跃，而是似乎在两条通路中作为胆碱能传递的相位调节剂发挥作用。
