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γ-氨基丁酸能对投射至额叶皮质的胆碱能神经纤维的调控不是持续性的。

GABAergic control of the cholinergic projections to the frontal cortex is not tonic.

作者信息

Blaker W D

出版信息

Brain Res. 1985 Jan 28;325(1-2):389-90. doi: 10.1016/0006-8993(85)90347-6.

DOI:10.1016/0006-8993(85)90347-6
PMID:3978431
Abstract

The turnover rate of acetylcholine was measured in the frontal cortex of rats after either microinjection of bicuculline into the substantia inominata (the source of the cortical cholinergic innervation) or kainic acid lesioning of the nucleus accumbens (the source of GABAergic innervation of the substantia inominata). Neither treatment affected cortical acetylcholine metabolism, suggesting that the GABAergic inhibition of the substantia inominata-cortical cholinergic pathway is not tonic.

摘要

在将荷包牡丹碱微量注射到无名质（皮质胆碱能神经支配的来源）或用红藻氨酸损伤伏隔核（无名质GABA能神经支配的来源）后，测量大鼠额叶皮质中乙酰胆碱的周转率。两种处理均未影响皮质乙酰胆碱代谢，这表明无名质 - 皮质胆碱能通路的GABA能抑制不是持续性的。

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