Resolving a paradox between mouse and man: a genetic link between TLR7 and the pathogenesis of human lupus nephritis.
作者信息
Jackson Shaun W, Rovin Brad H
机构信息
Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA; Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
Nephrology Division, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
出版信息
Kidney Int. 2023 May;103(5):824-826. doi: 10.1016/j.kint.2023.01.019.
Abstract
摘要
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本文引用的文献
1
TLR7 gain-of-function genetic variation causes human lupus.TLR7 获得性功能遗传变异导致人类狼疮。
Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27.
2
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial.奥滨尤妥珠单抗治疗增生性狼疮肾炎的 B 细胞耗竭：一项随机、双盲、安慰剂对照试验。
Ann Rheum Dis. 2022 Jan;81(1):100-107. doi: 10.1136/annrheumdis-2021-220920. Epub 2021 Oct 6.
3
Cellular aspects of the pathogenesis of lupus nephritis.狼疮肾炎发病机制的细胞方面。
Curr Opin Rheumatol. 2021 Mar 1;33(2):197-204. doi: 10.1097/BOR.0000000000000777.
4
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.由不受调控的Toll样受体7诱导的不同效应B细胞促成系统性红斑狼疮的致病反应。
Immunity. 2020 Jan 14;52(1):203. doi: 10.1016/j.immuni.2019.12.005.
5
Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.B 细胞固有 TLR7 和 TLR9 信号对自身抗体库和全身炎症的相反影响。
J Immunol. 2014 May 15;192(10):4525-32. doi: 10.4049/jimmunol.1400098. Epub 2014 Apr 7.
6
Integration of B cell responses through Toll-like receptors and antigen receptors.通过 Toll 样受体和抗原受体整合 B 细胞反应。
Nat Rev Immunol. 2012 Mar 16;12(4):282-94. doi: 10.1038/nri3190.
7
Fifty years of anti-ds DNA antibodies: are we approaching journey's end?抗双链DNA抗体五十年：我们是否已接近旅程终点？
Rheumatology (Oxford). 2007 Jul;46(7):1052-6. doi: 10.1093/rheumatology/kem112. Epub 2007 May 11.
8
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Toll样受体7和TLR9决定自身抗体特异性，并在狼疮小鼠模型中具有相反的炎症和调节作用。
Immunity. 2006 Sep;25(3):417-28. doi: 10.1016/j.immuni.2006.07.013.
9
Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus.多种自身抗体在系统性红斑狼疮患者体内形成肾小球免疫沉积物。
J Rheumatol. 2003 Jul;30(7):1495-504.
10
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.染色质-IgG复合物通过IgM和Toll样受体的双重作用激活B细胞。
Nature. 2002 Apr 11;416(6881):603-7. doi: 10.1038/416603a.
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