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Aerosolised antibiotics in critical care.

作者信息

Rello Jordi, Bouglé Adrien, Rouby Jean-Jacques

机构信息

Global Health eCore, Vall d'Hebron Institute of Research (VHIR), Ps. Vall d'Hebron 129. AMI-14, 08035, Barcelona, Spain.

Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

出版信息

Intensive Care Med. 2023 Jul;49(7):848-852. doi: 10.1007/s00134-023-07036-5. Epub 2023 Apr 21.

DOI:10.1007/s00134-023-07036-5
PMID:37085635
Abstract
摘要

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Monaldi Arch Chest Dis. 2011 Sep;75(3):155-6. doi: 10.4081/monaldi.2011.214.
4
High-flow oxygen therapy and other inhaled therapies in intensive care units.高流量氧疗和其他吸入疗法在重症监护病房。
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5
[Perspectives in the inhalative administration of drugs].[药物吸入给药的前景]
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Intensive Care Med. 2016 Feb;42(2):192-201. doi: 10.1007/s00134-015-4114-5. Epub 2015 Nov 24.
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Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?重症监护环境中的呼吸治疗。对于没有囊性纤维化的患者,是否应该给予雾化抗生素来预防或治疗呼吸机相关性肺炎?
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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies.雾化吸入氨基糖苷类药物治疗呼吸机相关性肺炎:方法学考量及实验研究的经验教训
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Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: A narrative review.了解重症患者的抗菌药物药代动力学以优化抗菌治疗:一篇叙述性综述。
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Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies.

本文引用的文献

1
Aerosol therapy during mechanical ventilation in intensive care units: A questionnaire-based survey of 2203 ICU medical staff in China.重症监护病房机械通气期间的雾化治疗:对中国2203名重症监护病房医护人员的问卷调查。
J Intensive Med. 2022 May 22;2(3):189-194. doi: 10.1016/j.jointm.2022.04.003. eCollection 2022 Jul.
2
Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis.非囊性纤维化支气管扩张症成人患者吸入性抗生素给药装置的安全性和有效性:一项系统评价和网状荟萃分析
Antibiotics (Basel). 2022 Feb 19;11(2):275. doi: 10.3390/antibiotics11020275.
3
理解抗生素雾化吸入:肺微透析研究的关键作用。
Crit Care. 2024 Feb 19;28(1):49. doi: 10.1186/s13054-024-04828-z.
4
Inhaled drug delivery: a randomized study in intubated patients with healthy lungs.吸入药物递送:一项针对肺部健康的插管患者的随机研究。
Ann Intensive Care. 2023 Dec 11;13(1):125. doi: 10.1186/s13613-023-01220-y.
5
The Use of an Inspiration-Synchronized Vibrating Mesh Nebulizer for Prolonged Inhalative Iloprost Administration in Mechanically Ventilated Patients-An In Vitro Model.在机械通气患者中使用吸气同步振动网式雾化器进行伊洛前列素的长时间吸入给药——体外模型
Pharmaceutics. 2023 Aug 3;15(8):2080. doi: 10.3390/pharmaceutics15082080.
6
Aerosol therapy in adult critically ill patients: a consensus statement regarding aerosol administration strategies during various modes of respiratory support.成人危重症患者的雾化治疗:关于不同呼吸支持模式下雾化给药策略的共识声明。
Ann Intensive Care. 2023 Jul 12;13(1):63. doi: 10.1186/s13613-023-01147-4.
Nebulized Antibiotics for Healthcare- and Ventilator-Associated Pneumonia.
用于医疗保健相关和呼吸机相关性肺炎的雾化抗生素
Semin Respir Crit Care Med. 2022 Apr;43(2):255-270. doi: 10.1055/s-0041-1740340. Epub 2022 Jan 18.
4
The Impact of High-Flow Nasal Cannula Device, Nebulizer Type, and Placement on Trans-Nasal Aerosol Drug Delivery.高流量鼻导管装置、雾化器类型和位置对经鼻气溶胶药物输送的影响。
Respir Care. 2022 Jan;67(1):1-8. doi: 10.4187/respcare.09133. Epub 2021 Oct 20.
5
Nebulized antibiotics for ventilator-associated pneumonia: methodological framework for future multicenter randomized controlled trials.雾化抗生素治疗呼吸机相关性肺炎:未来多中心随机对照试验的方法框架
Curr Opin Infect Dis. 2021 Apr 1;34(2):156-168. doi: 10.1097/QCO.0000000000000720.
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The IASIS, INHALE and VAPORISE trials. Reasons for a triple failure: Study design, aminoglycosides dosing and technique of nebulisation.IASIS、INHALE和VAPORISE试验。三重失败的原因:研究设计、氨基糖苷类药物剂量及雾化技术。
Anaesth Crit Care Pain Med. 2020 Apr;39(2):179-183. doi: 10.1016/j.accpm.2020.03.007. Epub 2020 Mar 7.
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Effect of adjunctive tobramycin inhalation versus placebo on early clinical response in the treatment of ventilator-associated pneumonia: the VAPORISE randomized-controlled trial.吸入用妥布霉素辅助治疗与安慰剂对呼吸机相关性肺炎早期临床反应的影响:VAPORISE随机对照试验
Intensive Care Med. 2020 Mar;46(3):546-548. doi: 10.1007/s00134-019-05914-5. Epub 2020 Jan 23.
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Lancet Infect Dis. 2020 Mar;20(3):330-340. doi: 10.1016/S1473-3099(19)30574-2. Epub 2019 Dec 19.
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Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD004197. doi: 10.1002/14651858.CD004197.pub5.
10
Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.雾化抗菌药物在侵袭性机械通气成人呼吸感染治疗中的应用:来自欧洲临床微生物学和传染病学会的立场文件。
Clin Microbiol Infect. 2017 Sep;23(9):629-639. doi: 10.1016/j.cmi.2017.04.011. Epub 2017 Apr 13.