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An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells.

作者信息

Zhao Yu, Cai Huihui, Ding Xiaoling, Zhou Xiaorong

机构信息

Department of Immunology, Nantong University, School of Medicine, Nantong, China.

Department of Gastroenterology, The Affiliated Hospital of Nantong University, Nantong, China.

出版信息

Funct Integr Genomics. 2023 Apr 22;23(2):136. doi: 10.1007/s10142-023-01056-6.

DOI:10.1007/s10142-023-01056-6
PMID:37086337
Abstract
摘要

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本文引用的文献

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Advances in the Lung Cancer Immunotherapy Approaches.肺癌免疫治疗方法的进展
Vaccines (Basel). 2022 Nov 19;10(11):1963. doi: 10.3390/vaccines10111963.
2
Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8 antigen-specific T cells for adoptive immunotherapy.联合阻断程序性死亡受体配体1（PD-L1）和T细胞免疫球蛋白和粘蛋白域3（TIM3）可改善适合过继性免疫治疗的人CD8抗原特异性T细胞的扩增。
Mol Ther Methods Clin Dev. 2022 Oct 4;27:230-245. doi: 10.1016/j.omtm.2022.09.016. eCollection 2022 Dec 8.
3
DUSP4 Silencing Enhances the Sensitivity of Breast Cancer Cells to Doxorubicin through the Activation of the JNK/c-Jun Signalling Pathway.
揭示肝硬化中CD8 + T细胞亚群的异质性：对疾病进展的影响
Gut Liver. 2025 May 15;19(3):410-426. doi: 10.5009/gnl230345. Epub 2024 Apr 16.
4
Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity.双特异性磷酸酶在调节肿瘤相关巨噬细胞活性中的作用。
Int J Mol Sci. 2023 Dec 16;24(24):17542. doi: 10.3390/ijms242417542.
DUSP4 沉默通过激活 JNK/c-Jun 信号通路增强乳腺癌细胞对阿霉素的敏感性。
Molecules. 2022 Sep 20;27(19):6146. doi: 10.3390/molecules27196146.
4
The Road Less Taken: Less Appreciated Pathways for Manipulating CD8 T Cell Exhaustion.少有人走的路：操纵 CD8 T 细胞耗竭的不那么被重视的途径。
Front Immunol. 2022 Jul 6;13:926714. doi: 10.3389/fimmu.2022.926714. eCollection 2022.
5
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.STAT3抑制剂与抗PD-1免疫疗法联合使用是一种治疗威罗菲尼耐药黑色素瘤的有效治疗方案。
Mol Ther Oncolytics. 2022 Jun 6;26:1-14. doi: 10.1016/j.omto.2022.06.001. eCollection 2022 Sep 15.
6
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.DUSP4 通过调节 MITF 来保护 BRAF 和 NRAS 突变型黑色素瘤免受致癌基因过表达的影响。
Life Sci Alliance. 2022 May 17;5(9). doi: 10.26508/lsa.202101235. Print 2022 Sep.
7
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Clin Transl Med. 2022 Feb;12(2):e730. doi: 10.1002/ctm2.730.
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma.单细胞转录组分析揭示了 EGFR 突变型肺腺癌中抑制性的肿瘤免疫微环境。
J Immunother Cancer. 2022 Jan;10(2). doi: 10.1136/jitc-2021-003534.
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Dual-specificity phosphatases: therapeutic targets in cancer therapy resistance.双特异性磷酸酶：癌症治疗耐药性中的治疗靶点。
J Cancer Res Clin Oncol. 2022 Jan;148(1):57-70. doi: 10.1007/s00432-021-03874-2. Epub 2022 Jan 4.