Graduate School of Natural Science, Konan University, Kobe 658-8501, Japan; Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan; Institute for Integrative Neurobiology, Konan University, Kobe 658-8501, Japan; AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
Graduate School of Natural Science, Konan University, Kobe 658-8501, Japan; Institute for Integrative Neurobiology, Konan University, Kobe 658-8501, Japan.
Neurosci Res. 2023 Sep;194:1-6. doi: 10.1016/j.neures.2023.04.005. Epub 2023 Apr 20.
Acclimation to temperature is one of the survival strategies used by organisms to adapt to changing environmental temperatures. Caenorhabditis elegans' cold tolerance is altered by previous cultivation temperature, and similarly, past low-temperature induces a longer lifespan. Temperature is thought to cause a large shift in homeostasis, lipid metabolism, and reproduction in the organism because it is a direct physiological factor during chemical events. This paper will share and discuss what we know so far about the neural and molecular mechanisms that control cold tolerance and lifespan by altering lipid metabolism and physiological characteristics. We hope that this will contribute to a better understanding of how organisms respond to temperature changes.
适应温度是生物体用来适应环境温度变化的生存策略之一。秀丽隐杆线虫的耐寒性受先前培养温度的影响，同样，过去的低温会诱导更长的寿命。由于温度是化学事件过程中的直接生理因素，因此它被认为会导致生物体的体内平衡、脂质代谢和繁殖发生巨大变化。本文将分享和讨论我们目前对通过改变脂质代谢和生理特性来控制耐寒性和寿命的神经和分子机制的了解。我们希望这将有助于更好地理解生物体如何应对温度变化。
