University of São Paulo, Rua Arlindo Bettio, 1000, Vila Guaraciaba, São Paulo, 01000-000, São Paulo, Brazil.
J Biomed Inform. 2023 Jun;142:104366. doi: 10.1016/j.jbi.2023.104366. Epub 2023 Apr 21.
Segmentation of the left ventricle is a key approach in Cardiac Magnetic Resonance Imaging for calculating biomarkers in diagnosis. Since there is substantial effort required from the expert, many automatic segmentation methods have been proposed, in which deep learning networks have obtained remarkable performance. However, one of the main limitations of these approaches is the production of segmentations that contain anatomical errors. To avoid this limitation, we propose a new fully-automatic left ventricle segmentation method combining deep learning and deformable models. We propose a new level set energy formulation that includes exam-specific information estimated from the deep learning segmentation and shape constraints. The method is part of a pipeline containing pre-processing steps and a failure correction post-processing step. Experiments were conducted with the Sunnybrook and ACDC public datasets, and a private dataset. Results suggest that the method is competitive, that it can produce anatomically consistent segmentations, has good generalization ability, and is often able to estimate biomarkers close to the expert.
左心室分割是心脏磁共振成像中计算诊断生物标志物的关键方法。由于专家需要付出大量的努力,因此已经提出了许多自动分割方法,其中深度学习网络取得了显著的性能。然而,这些方法的主要限制之一是产生包含解剖学错误的分割。为了避免这种限制,我们提出了一种新的结合深度学习和可变形模型的全自动左心室分割方法。我们提出了一种新的水平集能量公式,其中包括从深度学习分割中估计的特定于检查的信息和形状约束。该方法是包含预处理步骤和故障校正后处理步骤的流水线的一部分。实验是在 Sunnybrook 和 ACDC 公共数据集以及一个私人数据集上进行的。结果表明,该方法具有竞争力,能够产生解剖一致的分割,具有良好的泛化能力,并且通常能够估计接近专家的生物标志物。