Effective detection of Alzheimer's disease by optimizing fuzzy K-nearest neighbors based on salp swarm algorithm.

Alzheimer's disease (AD) is a typical senile degenerative disease that has received increasing attention worldwide. Many artificial intelligence methods have been used in the diagnosis of AD. In this paper, a fuzzy k-nearest neighbor method based on the improved binary salp swarm algorithm (IBSSA-FKNN) is proposed for the early diagnosis of AD, so as to distinguish between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD) and normal controls (NC). First, the performance and feature selection accuracy of the method are validated on 5 different benchmark datasets. Secondly, the paper uses the Structural Magnetic Resolution Imaging (sMRI) dataset, in terms of classification accuracy, sensitivity, specificity, etc., the effectiveness of the method on the AD dataset is verified. The simulation results show that the classification accuracy of this method for AD and MCI, AD and NC, MCI and NC are 95.37%, 100%, and 93.95%, respectively. These accuracies are better than the other five comparison methods. The method proposed in this paper can learn better feature subsets from serial multimodal features, so as to improve the performance of early AD diagnosis. It has a good application prospect and will bring great convenience for clinicians to make better decisions in clinical diagnosis.