非编码 RNA 在类风湿关节炎发病机制中的功能和网络。
The functions and networks of non-coding RNAs in the pathogenesis of Rheumatoid Arthritis.
机构信息
Department of Rheumatology, The Second Hospital of Shanxi Medical University, China; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, China.
Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, China.
出版信息
Biomed Pharmacother. 2023 Jul;163:114707. doi: 10.1016/j.biopha.2023.114707. Epub 2023 Apr 21.
Rheumatoid Arthritis (RA) is a chronic autoimmune disease. Its main feature is inflammation of synovial tissue with irreversible joint damage and severe physical damage. Non-coding RNAs (ncRNAs) are a class of RNAs that do not have the ability to encode proteins but are vital regulators that mediate many fundamental cellular processes and play an essential role in the pathogenesis of RA. Multiple verified ncRNAs have been confirmed as a prospective biomarkers for diagnosing and treating RA. In this paper, we aim to sort out the role of ncRNAs in the pathogenesis of RA and provide new ideas for the diagnosis and treatment of RA.
类风湿关节炎（RA）是一种慢性自身免疫性疾病。其主要特征是滑膜组织炎症，伴有不可逆的关节损伤和严重的身体损害。非编码 RNA（ncRNA）是一类不具有编码蛋白质能力的 RNA，但却是重要的调控因子，介导许多基本的细胞过程，并在 RA 的发病机制中发挥重要作用。多种经过验证的 ncRNA 已被确认为诊断和治疗 RA 的有前途的生物标志物。本文旨在梳理 ncRNA 在 RA 发病机制中的作用，为 RA 的诊断和治疗提供新的思路。
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