Ghaleb Christina, Penney Danielle, Lavigne Katie M, Raucher-Chéné Delphine
Douglas Research Center, Montreal, Quebec, Canada.
Department of Psychology, McGill University, Montreal, Quebec, Canada.
Early Interv Psychiatry. 2025 Jun;19(6):e70058. doi: 10.1111/eip.70058.
Bipolar disorder (BD) is a severe, persistent disorder that causes functional impairment. Besides heritability, environmental factors, such as traumatic experience, impact the development of BD. Little is known about the early developmental signs of this disorder; therefore, this study aims to look at the impact of interpersonal trauma on the early developmental signs of BD. Specifically, differences in psychopathological behaviours were investigated between (1) at-risk children and controls and (2) at-risk children who experienced an interpersonal traumatic event and those who did not.
Using the Adolescent Brain Cognitive Development (ABCD) dataset, participants with a first-degree relative with BD were identified (N = 625) and matched on sex and age to a control group (N = 625). The Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) was used to assess interpersonal trauma and psychopathological symptoms. The trauma (N = 198) and no-trauma sub-groups (N = 428) were built from the at-risk population. Group comparison was conducted on depressive, manic and anxiety symptoms.
Compared to controls, at-risk children exhibited a significantly greater number of manic symptoms at baseline and 2-year follow-up, and anxiety symptoms at follow-up. No significant differences were found between the trauma and no-trauma groups at either baseline or follow-up.
These results confirm the presence of early symptoms in at-risk children, in line with the staging model of BD. Extended longitudinal research is needed to further investigate the potential specific role of trauma on its early behavioural patterns.
双相情感障碍（BD）是一种严重的持续性疾病，会导致功能受损。除遗传因素外，创伤经历等环境因素也会影响双相情感障碍的发展。关于这种疾病的早期发育迹象知之甚少；因此，本研究旨在探讨人际创伤对双相情感障碍早期发育迹象的影响。具体而言，研究了（1）高危儿童与对照组之间以及（2）经历人际创伤事件的高危儿童与未经历此类事件的高危儿童之间心理病理行为的差异。
使用青少年大脑认知发展（ABCD）数据集，确定有双相情感障碍一级亲属的参与者（N = 625），并按性别和年龄与对照组（N = 625）进行匹配。使用儿童情感障碍和精神分裂症评定量表（KSADS）评估人际创伤和心理病理症状。从高危人群中构建创伤亚组（N = 198）和无创伤亚组（N = 428）。对抑郁、躁狂和焦虑症状进行组间比较。
与对照组相比，高危儿童在基线和2年随访时出现的躁狂症状明显更多，在随访时出现的焦虑症状也更多。在基线或随访时，创伤组和无创伤组之间均未发现显著差异。
这些结果证实了高危儿童存在早期症状，这与双相情感障碍的分期模型一致。需要进行进一步的纵向研究，以进一步探讨创伤在其早期行为模式中的潜在特定作用。
