Department Molecular genetics and DNA fingerprinting, Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq.
Ministy of Health/medical Legal Dirctorate /paternity and Kinship Section, Iraq.
Gene. 2023 Jul 1;872:147440. doi: 10.1016/j.gene.2023.147440. Epub 2023 Apr 23.
Iraq is home to the ancient civilization, of Mesopotamia. The population genetics of Iraqis is important due to their ethnic diversity. This study aimed to analyze is to analyze the distribution of Y chromosome haplotypes in a sample of 680 native Iraqi males from regions of Iraq and compare it to previously published Y chromosome haplotype data from some neighboring Arab populations.In this study, A total of 680 unrelated samples (not belonging to the same nuclear family) of healthy males were sampled for the Y-STR analysis from the Iraqi populations in Baghdad. blood samples were collected at the ministry of health/medical legal Directorate/paternity and Baghdad from 2018 to 2020. Allele frequency and gene diversity were calculated. The Iraqi population data were compared with the neighboring populations using pairwise genetic distances using the Y Chromosome Haplotype Reference Database Website (YHRD) software.The discrimination capacity 23 STR loci provide was (0.92). The number of haplotypes observed in 680 samples, was 616 haplotypes (568 unique and 48 shared haplotypes). Haplogroup prediction suggests that haplogroup J1 is the most common in the Iraqi population, followed by J2. According to AMOVA and MD, showed high similarities with neighboring countries. We can conclude that there is no genetic structure among the populations and their data could be added to reference the Iraqi database.
伊拉克是美索不达米亚古代文明的发源地。由于伊拉克人种族多样，他们的人口遗传学很重要。本研究旨在分析来自伊拉克不同地区的 680 名伊拉克男性样本中的 Y 染色体单倍型分布，并将其与之前发表的一些邻近阿拉伯人群的 Y 染色体单倍型数据进行比较。在这项研究中，从 2018 年到 2020 年，在巴格达的伊拉克卫生部/医疗法律局/亲子鉴定部门收集了 680 名（不属于同一核心家庭）无关男性的 Y-STR 分析血样。计算了等位基因频率和基因多样性。使用 Y 染色体单倍型参考数据库网站 (YHRD) 软件，通过基因距离的成对比较，将伊拉克人群数据与邻近人群进行比较。23 个 STR 基因座的鉴别能力为 0.92。在 680 个样本中观察到的单倍型数量为 616 个单倍型（568 个独特单倍型和 48 个共享单倍型）。单倍型预测表明，在伊拉克人群中，J1 单倍型最为常见，其次是 J2。根据 AMOVA 和 MD，与邻国表现出高度相似性。我们可以得出结论，人群之间没有遗传结构，他们的数据可以添加到伊拉克数据库中作为参考。
