Pu Feifei, Yu Yihan, Zhang Zhicai, Wu Wei, Shao Zengwu, Li Chao, Feng Jing, Xue Longjian, Chen Fengxia
Department of Orthopedics, Traditional Chinese and Western Medicine Hospital of Wuhan (Wuhan No.1 Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Macromol Biosci. 2023 Sep;23(9):e2300032. doi: 10.1002/mabi.202300032. Epub 2023 May 21.
Polyetheretherketone (PEEK) can potentially be used for bone repair because its elastic modulus is similar to that of human natural bone and good biocompatibility and chemical stability. However, its hydrophobicity and biological inertness limit its application in the biomedical field. Inspired by the composition, structure, and function of bone tissue, many strategies are proposed to change the structure and functionality of the PEEK surface. In this review, the applications of PEEK in bone repair and the optimization strategy for PEEK's biological activity are reviewed, which provides a direction for the development of multifunctional bone repair materials in the future.
聚醚醚酮(PEEK)因其弹性模量与人体天然骨相似,且具有良好的生物相容性和化学稳定性,因而具有用于骨修复的潜力。然而,其疏水性和生物惰性限制了它在生物医学领域的应用。受骨组织的组成、结构和功能启发,人们提出了许多改变PEEK表面结构和功能的策略。本文综述了PEEK在骨修复中的应用以及PEEK生物活性的优化策略,为未来多功能骨修复材料的发展提供了方向。