Mas A, Peligero M J, Arola L, Alemany M
Clin Exp Pharmacol Physiol. 1986 Feb;13(2):91-6. doi: 10.1111/j.1440-1681.1986.tb00321.x.
Radioactive nickel (Ni) was injected intraperitoneally both carrier-free and in 4 mg/kg body weight of Ni as NiCl2 doses in control and pregnant rats on days 12 and 19 after impregnation. The time-course of disappearance of radioactivity from the tissues and blood of the rat was determined, as well as the degree of incorporation of radioactivity from the injected doses. The maximal uptake of the metal 15 min after injection corresponded to kidney uptake, followed by pancreas, blood plasma and then all other target organs studied. The presence of cold nickel resulted in higher uptake of the metal without much change in the proportion of distribution between tissues. The kinetics of disappearance was similar in all tissues and was little affected by pregnancy, with mean half-lives of about 3-5 h irrespective of doses.
在受孕后第12天和第19天，给对照组和怀孕大鼠腹腔注射无载体放射性镍（Ni）以及以NiCl₂形式存在的4mg/kg体重的镍剂量。测定了镍从大鼠组织和血液中消失的时间进程，以及注射剂量中放射性物质的掺入程度。注射后15分钟，金属的最大摄取量对应于肾脏摄取，其次是胰腺、血浆，然后是所有其他研究的靶器官。冷镍的存在导致金属摄取量增加，而组织间分布比例变化不大。所有组织中镍消失的动力学相似，且受怀孕影响较小，无论剂量如何，平均半衰期约为3 - 5小时。
