Gunn H C, Ryffel B
Clin Nephrol. 1986;25 Suppl 1:S189-92.
Female NZB/W hybrid mice spontaneously develop autoimmune glomerulonephritis (GN) at the age of 3 to 6 months. The aim of the present study was to investigate the effects of cyclosporine (CS) on proteinuria and GN in mice at various stages of the disease, e.g., 12, 24 and 48 weeks of age. A 12 week course of CS (100 mg/kg/day) either abolished or prevented the development of proteinuria depending on the disease stage. Histologically, CS prevented the further development or even reversed GN. Immunoglobulin (Ig) and complement (C') deposition in the glomeruli were also reduced in CS-treated mice. These results indicate that CS has a therapeutic effect in murine autoimmune GN.
雌性新西兰黑/白杂交小鼠在3至6个月大时会自发患上自身免疫性肾小球肾炎（GN）。本研究的目的是调查环孢素（CS）对处于疾病不同阶段（如12周、24周和48周龄）小鼠蛋白尿和GN的影响。根据疾病阶段，为期12周的CS（100毫克/千克/天）疗程要么消除要么预防了蛋白尿的发展。从组织学上看，CS阻止了GN的进一步发展甚至使其逆转。在接受CS治疗的小鼠中，肾小球内免疫球蛋白（Ig）和补体（C'）沉积也减少了。这些结果表明CS对小鼠自身免疫性GN有治疗作用。
