Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
Neurosci Lett. 2020 Nov 1;738:135382. doi: 10.1016/j.neulet.2020.135382. Epub 2020 Sep 12.
Multiple sclerosis is an inflammatory and neurodegenerative disease of the central nervous system in which the immune cells attack the myelin sheath of the nerves, leading to axonal damage, inflammation, immune cell infiltration, and demyelination of the brain and spinal cord. These detrimental changes cause some impairments, such as depression, motor deficit, and cognitive dysfunction, affecting the quality of life in MS patients and their social activities. The present study assessed the impact of 6-week voluntary exercise prior to disease onset on the expression of Nrf-2, IL-10, IL-17, as well as the degree of lymphocyte infiltration in the spinal cord and disease severity in the chronic period of the EAE (30 days post-induction). The results showed that voluntary wheel running stimulated the expression of Nrf-2 and IL-10, while decreased the expression of IL-17, the rate of lymphocyte infiltration, and the severity of EAE at the chronic period of the disease. Thus, alterations in lifestyle, such as regular exercise, may modulate inflammation and disease severity in patients with MS.
多发性硬化症是一种中枢神经系统的炎症性和神经退行性疾病，其中免疫细胞攻击神经的髓鞘，导致轴突损伤、炎症、免疫细胞浸润和大脑及脊髓脱髓鞘。这些有害变化导致一些损伤，如抑郁、运动缺陷和认知功能障碍，影响多发性硬化症患者的生活质量和社会活动。本研究评估了疾病发作前 6 周的自愿运动对 Nrf-2、IL-10、IL-17 的表达以及脊髓淋巴细胞浸润程度和 EAE 慢性期（诱导后 30 天）疾病严重程度的影响。结果表明，自愿轮式跑步刺激了 Nrf-2 和 IL-10 的表达，同时降低了 IL-17、淋巴细胞浸润率和疾病慢性期 EAE 的严重程度。因此，生活方式的改变，如定期运动，可能调节多发性硬化症患者的炎症和疾病严重程度。
