维持性血液透析患者血清成纤维细胞生长因子23及慢性肾脏病-矿物质和骨异常标志物与心脏结构变化的相关性
Correlation of Serum FGF23 and Chronic Kidney Disease-Mineral and Bone Abnormality Markers With Cardiac Structure Changes in Maintenance Hemodialysis Patients.
作者信息
Zeng Dewang, Zha Aiyun, Lei Ying, Yu Zongchao, Cao Rui, Li Ling, Song Zhuoheng, Li Weilong, Li Yunyi, Liu Haiping, Huang Shaoxing, Dong Xiangnan, Krämer Bernhard, Hocher Berthold, Yin Lianghong, Yun Chen, Morgera Stanislao, Guan Baozhang, Meng Yu, Liu Fanna, Hu Bo, Luan Shaodong
机构信息
Department of Nephrology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Department of Nephrology, Huadu District People's Hospital, Guangzhou, China.
出版信息
Evid Based Complement Alternat Med. 2023 Apr 8;2023:6243771. doi: 10.1155/2023/6243771. eCollection 2023.
BACKGROUND
CKD-MBD is a mineral and bone metabolism syndrome caused by chronic kidney disease. FGF23 is an important factor regulating phosphorus and is the main influencer in the CKD-MBD process. In this study, we observed the correlation among serum FGF23 and calcium, phosphorus and parathyroid hormone, and the correlation between FGF23 levels and cardiac structural changes in MHD patients.
METHODS
We examined serum FGF23 concentrations in 107 cases of MHD patients using the ELISA method, recorded demographic information and biochemical data, and analyzed the correlation between serum FGF23 levels and blood calcium and blood phosphorus and PTH levels. All patients were evaluated by cardiac color ultrasound, and we finally analyzed the association between the FGF23 level and cardiac structural changes.
RESULTS
In 107 cases of MHD patients, serum FGF23 levels were linearly associated with serum calcium ( = 0.27 < 0.01) and parathyroid hormone levels ( = 0.25, < 0.05). FGF 23 was negatively correlated with age ( = -0.44, < 0.01).Serum FGF23 levels were correlated with right atrial hypertrophy in HD patients ( < 0.05). No correlation was found among FGF23, left ventricular hypertrophy/enlargement, and valve calcification stenosis ( > 0.05).
CONCLUSION
Serum FGF23 showed a positive correlation among blood calcium levels and PTH levels in hemodialysis patients, and FGF23 levels can affect the incidence of right atrial hypertrophy in MHD patients.
背景
慢性肾脏病矿物质和骨代谢紊乱（CKD-MBD）是一种由慢性肾脏病引起的矿物质和骨代谢综合征。成纤维细胞生长因子23（FGF23）是调节磷的重要因子，也是CKD-MBD过程中的主要影响因素。在本研究中，我们观察了维持性血液透析（MHD）患者血清FGF23与钙、磷及甲状旁腺激素之间的相关性，以及FGF23水平与心脏结构变化之间的相关性。
方法
我们采用酶联免疫吸附测定（ELISA）法检测了107例MHD患者的血清FGF23浓度，记录了人口统计学信息和生化数据，并分析了血清FGF23水平与血钙、血磷及甲状旁腺激素（PTH）水平之间的相关性。所有患者均接受心脏彩色超声检查，最后分析FGF23水平与心脏结构变化之间的关联。
结果
在107例MHD患者中，血清FGF23水平与血清钙（r = 0.27，P < 0.01）和甲状旁腺激素水平（r = 0.25，P < 0.05）呈线性相关。FGF23与年龄呈负相关（r = -0.44，P < 0.01）。血清FGF23水平与血液透析患者右心房肥厚相关（P < 0.05）。未发现FGF23与左心室肥厚/扩大及瓣膜钙化狭窄之间存在相关性（P > 0.05）。
结论
血液透析患者血清FGF23水平与血钙水平及PTH水平呈正相关，且FGF23水平可影响MHD患者右心房肥厚的发生率。
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