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两例免疫检查点抑制剂诱发的伴有完全性房室传导阻滞的心肌炎

Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block.

作者信息

Kondo Hisaya, Kirigaya Jin, Matsuzawa Yasushi, Hibi Kiyoshi

机构信息

Cardiology, Yokohama City University Medical Center, Yokohama, JPN.

Emergency and Critical Care, Yokohama City University Medical Center, Yokohama, JPN.

出版信息

Cureus. 2023 Mar 21;15(3):e36446. doi: 10.7759/cureus.36446. eCollection 2023 Mar.

Abstract

Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use.

摘要

据报道,免疫检查点抑制剂诱发的心肌炎(ICIM)可并发完全性房室传导阻滞。尽管在其治疗中使用了类固醇,但对于类固醇的使用尚无标准方案。我们报告了两例伴有完全性房室传导阻滞的ICIM病例,其结局不同。在第一例中,完全性房室传导阻滞未恢复。相比之下,在第二例中,完全性房室传导阻滞确实恢复了。我们讨论了这两例病例在类固醇使用方面的不同病程和结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a588/10115746/405aea4d56f0/cureus-0015-00000036446-i01.jpg

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