含PRF与不含PRF的4MATRIX对骨下袋牙周袋再生效果的比较分析

Comparative analysis of the effect of 4MATRIX with and without PRF on regeneration of infrabony periodontal pockets.

作者信息

Reçica Bylbyl, Bukleta Dashnor, Popovska Mirjana, Tefiku Urim, Ahmedi Jehona, Stubljar David

机构信息

Department of Oral Surgery, College of Medical Sciences Rezonanca, Prishtina, Republic of Kosovo.

Department of Periodontology and Oral Pathology, University Dental Clinical Centre "Ss. Cyril and Methodius University", Skopje, The Former Yugolav Republic of Macedonia.

出版信息

Saudi Dent J. 2023 Mar;35(3):244-250. doi: 10.1016/j.sdentj.2023.01.011. Epub 2023 Feb 6.

DOI:10.1016/j.sdentj.2023.01.011

PMID:37091276

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10114591/

Abstract

AIM

The aim was to compare the effect in improvement of periodontal pocket depth (PPD) and clinical attachment level (CAL) between application of 4MATRIX and 4 MATRIX combined with PRF in advanced periodontal disease during follow-up of 6, 12 and 18 months.

METHODS

Thirty patients of both genders aged 25-50 years were included. The patients were clinically and radiologically diagnosed with generalized advanced chronic periodontitis with the presence of periodontal pockets with a depth of ≥ 5 mm bilaterally in the upper jaw. Both sides were treated with a flap intervention in all patients. On one side a bone substitute 4MATRIX was applied, and the other side was treated with an application 4MATRIX and PRF. The clinical assessment and measurements were performed in four stages, immediately before the intervention, and then 6, 12 and 18 months after the intervention. PPD and CAL were determined in all four timepoints.

RESULTS

PPD was the highest at zero time before the surgery for both groups and was 5.56 ± 0.28 mm. In the postoperative follow-up period, the PPD value decreased gradually with the lowest average value of 5.10 ± 0.18 mm after 18 months in Group I and 4.67 ± 0.13 mm in Group II (p < 0.001, respectively). Moreover, comparing the values of PPD at 6, 12 and 18 months after the surgery, a significant difference was found between the patients from the 4MATRIX vs 4MATRIX + PRF (p < 0.001 respectively). The postoperative follow-up period showed a decrease in CAL value with the lowest value after 18 months. A significant difference in CAL was found between the four measurement times (p < 0.001, respectively). The average level of CAL was the highest before surgical treatment in both groups. The intergroup analysis of CAL after 18 months in group I (4MATRIX) was 5.27 ± 0.17 mm and in group II 4.10 ± 0.14 mm (p < 0.001).

CONCLUSION

Treatment of adult patients with advanced chronic periodontitis with periodontal pockets of ≥ 5 mm bilaterally in the upper jaw using 4MATRIX and 4MATRIX + PRF showed improvement of PPD and lower CAL loss after 18 months of the treatment. In the group treated with 4MATRIX + PRF patients showed the highest improvement in PPD and CAL loss. The analysis of treatment with 4MATRIX and 4MATRIX + PRF showed the lowest values after 18 months of the treatment.

摘要

目的

旨在比较在6个月、12个月和18个月的随访期内，4MATRIX以及4MATRIX联合PRF应用于重度牙周病时，对改善牙周袋深度（PPD）和临床附着水平（CAL）的效果。

方法

纳入30例年龄在25 - 50岁的男女患者。这些患者经临床和影像学诊断为广泛性重度慢性牙周炎，上颌双侧均存在深度≥5mm的牙周袋。所有患者双侧均接受翻瓣手术干预。一侧应用骨替代材料4MATRIX，另一侧应用4MATRIX和PRF。在干预前即刻以及干预后6个月、12个月和18个月这四个阶段进行临床评估和测量。在所有四个时间点测定PPD和CAL。

结果

两组患者术前零时间点的PPD最高，为5.56±0.28mm。在术后随访期，PPD值逐渐降低，I组18个月后平均值最低，为5.10±0.18mm，II组为4.67±0.13mm（p均<0.001）。此外，比较术后6个月、12个月和18个月时的PPD值，4MATRIX组与4MATRIX + PRF组患者之间存在显著差异（p均<0.001）。术后随访期CAL值降低，18个月后达到最低值。四个测量时间点的CAL存在显著差异（p均<0.001）。两组手术治疗前CAL平均水平最高。I组（4MATRIX）18个月后的CAL组间分析为5.27±0.17mm，II组为4.10±0.14mm（p<0.001）。

结论

使用4MATRIX和4MATRIX + PRF治疗上颌双侧牙周袋深度≥5mm的成年重度慢性牙周炎患者，治疗18个月后PPD有所改善，CAL丧失减少。在4MATRIX + PRF治疗组中，患者的PPD改善和CAL丧失情况最为显著。4MATRIX和4MATRIX + PRF治疗分析显示，治疗18个月后数值最低。