Upadhyay Himani, Bhattacharya Hirak S, Agarwal Manvi Chandra, Manjunath R G Shiva, Agarwal Ashutosh, Upadhyay Himanshu
Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
Contemp Clin Dent. 2020 Jul-Sep;11(3):217-222. doi: 10.4103/ccd.ccd_7_19. Epub 2020 Nov 26.
Platelet concentrates usage in the treatment of intrabony defects has been improved due to advancement of research. Many generation of platelet concentrates were used, but research regarding advanced platelet-rich fibrin (A-PRF) regarding periodontal treatment is scanty.
The purpose of the study was to evaluate and compare PRF and A-PRF in the treatment of human periodontal infrabony defects (IBDs) both clinically and radiographically.
Twenty-eight patients having IBDs were divided into Group A (PRF) and Group B (A-PRF). Clinical parameters such as plaque index, gingival index, probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and 3 and 6 months and radiographic examination at baseline and 6 months were also recorded to evaluate defect fill, resolution, and change in the alveolar crest height. Then, all the data were tabulated in a Microsoft Excel sheet and subjected to statistical analysis. Mean and standard deviations of the clinical and radiographic parameters were calculated, and unpaired -test was performed to assess intergroup comparison at different time intervals.
Intragroup comparison showed statistically significant improvement in PPD and CAL at 3 and 6 months while statistically significant improvement was observed in mean defect fill and resolution in Group B.
Individually, both the materials have shown promising results. However, statistically, PRF group (Group A) showed better treatment outcome in terms of bone fill and A-PRF group (Group B) in terms of soft tissue healing.
随着研究的进展，血小板浓缩物在骨内缺损治疗中的应用得到了改善。已使用了多代血小板浓缩物，但关于高级富血小板纤维蛋白（A-PRF）用于牙周治疗的研究却很少。
本研究的目的是从临床和影像学方面评估和比较PRF和A-PRF在治疗人类牙周骨下袋缺损（IBD）中的效果。
28例患有IBD的患者被分为A组（PRF）和B组（A-PRF）。在基线、3个月和6个月时记录菌斑指数、牙龈指数、探诊深度（PPD）和临床附着水平（CAL）等临床参数，并在基线和6个月时进行影像学检查，以评估缺损填充、消退情况以及牙槽嵴高度的变化。然后，将所有数据整理到Microsoft Excel工作表中并进行统计分析。计算临床和影像学参数的均值和标准差，并进行非配对t检验以评估不同时间间隔的组间比较。
组内比较显示，在3个月和6个月时PPD和CAL有统计学意义的改善，而B组在平均缺损填充和消退方面有统计学意义的改善。
单独来看，两种材料都显示出了有前景的结果。然而，从统计学角度来看，PRF组（A组）在骨填充方面显示出更好的治疗效果，而A-PRF组（B组）在软组织愈合方面效果更佳。
