Bruze M, Persson L, Trulsson L, Zimerson E
Contact Dermatitis. 1986 Mar;14(3):146-54. doi: 10.1111/j.1600-0536.1986.tb01194.x.
12 phenol-formaldehyde resins were investigated with regard to the presence of 14 contact sensitizers by using high-pressure liquid chromatography. The allergens consisted of simple methylol phenols, dihydroxydiphenyl methanes, 4,4(1)-dihydroxy-(hydroxymethyl)-diphenyl methanes and 2,4(1)-dihydroxy-(hydroxymethyl)-diphenyl methanes. Four substances, 2,4-dimethylol phenol, 2,6-dimethylol phenol, 4,4(1)-dihydroxydiphenyl methane and 2,4(1)-dihydroxydiphenyl methane, were isolated from a resol resin and identified by mass-spectrometry and nuclear magnetic resonance spectrometry. The highest concentrations (up to 15% w/w) of allergens were noted for methylol phenols in resol resins based on phenol and formaldehyde. The corresponding novolak resins showed a high content of dihydroxydiphenyl methanes. There was great variation in concentration of the sensitizers between the resins. None of these sensitizers were demonstrated in the resin based on paratertiary-butyl phenol. Products based on phenol-formaldehyde resins were also investigated for the presence of allergens. Uncured impregnated paper for laminate production and uncured mineral wool contained the same concentrations of the sensitizers as some of the resins studied. The curing process decreased the content of all the allergens investigated in all products, but the sensitizers did not disappear, and they may thus be present in finished products.
通过高压液相色谱法，对12种酚醛树脂中14种接触性致敏剂的存在情况进行了研究。这些过敏原包括简单的羟甲基酚、二羟基二苯甲烷、4,4(1)-二羟基-(羟甲基)-二苯甲烷和2,4(1)-二羟基-(羟甲基)-二苯甲烷。从一种甲阶酚醛树脂中分离出了四种物质，即2,4-二羟甲基酚、2,6-二羟甲基酚、4,4(1)-二羟基二苯甲烷和2,4(1)-二羟基二苯甲烷，并通过质谱和核磁共振光谱进行了鉴定。基于苯酚和甲醛的甲阶酚醛树脂中，羟甲基酚的过敏原浓度最高（高达15% w/w）。相应的线型酚醛树脂中二羟基二苯甲烷含量较高。不同树脂之间致敏剂的浓度差异很大。在对叔丁基苯酚基树脂中未检测到这些致敏剂中的任何一种。还对基于酚醛树脂的产品中的过敏原存在情况进行了研究。用于层压板生产的未固化浸渍纸和未固化矿棉中致敏剂的浓度与所研究的一些树脂相同。固化过程降低了所有产品中所研究的所有过敏原的含量，但致敏剂并未消失，因此它们可能存在于成品中。
