血清胱抑素 C 与空洞性肺结核的关系。
Association between Serum Cys C and PTB Cavitation.
机构信息
Department of Clinical Laboratory, Haikou City People's Hospital, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, Hainan, China.
出版信息
Dis Markers. 2023 Apr 12;2023:6465182. doi: 10.1155/2023/6465182. eCollection 2023.
BACKGROUND
Cystatin C (Cys C) not only regulates the body's immune defenses but also contributes to tissue degradation and destruction by causing an imbalance between protease and antiprotease in infectious diseases. Is Cys C involved in pulmonary tuberculosis (PTB) infection and cavitation? We therefore conducted a retrospective study on this question to provide a basis for further studies.
METHODS
Cavitary PTB patients, noncavitary PTB patients, and healthy controls were recruited in our study. Serum Cys C, CRP, BUN, UA, and CR were measured in all subjects, and the Kruskal-Wallis test was used to compare medians of these clinical parameters in different groups. The Spearman rank correlation test was used to determine correlations between variables. In addition, a multivariate analysis using binary logistic regression was used to identify factors associated with PTB cavitation.
RESULTS
In our study, elevated serum Cys C levels were found in cavitary PTB patients compared to healthy controls and noncavitary patients ( = 0.022). Serum Cys C levels were statistically correlated with serum BUN and CR concentrations ( = 0.278, = 0.005; = 0.281, = 0.004) in PTB patients. The binary logistic regression analysis showed that elevated serum Cys C levels were correlated with pulmonary cavitation in PTB patients (OR = 1.426, 95% CI: 1.071-1.898).
CONCLUSION
Elevated serum levels of Cys C are associated with pulmonary cavitation in PTB patients.
背景
胱抑素 C（Cys C）不仅调节机体的免疫防御功能，而且在传染病中通过引起蛋白酶与抗蛋白酶之间的失衡，导致组织降解和破坏。Cys C 是否参与肺结核（PTB）感染和空洞形成？因此，我们对此进行了回顾性研究，为进一步研究提供了依据。
方法
本研究纳入了空洞性肺结核患者、非空洞性肺结核患者和健康对照者。所有受试者均检测血清 Cys C、CRP、BUN、UA 和 CR，采用 Kruskal-Wallis 检验比较不同组间这些临床参数的中位数。采用 Spearman 秩相关检验确定变量之间的相关性。此外，采用二元逻辑回归的多变量分析来确定与 PTB 空洞形成相关的因素。
结果
本研究发现，与健康对照组和非空洞性患者相比，空洞性肺结核患者的血清 Cys C 水平升高（ = 0.022）。在肺结核患者中，血清 Cys C 水平与血清 BUN 和 CR 浓度呈统计学相关（ = 0.278， = 0.005； = 0.281， = 0.004）。二元逻辑回归分析显示，肺结核患者中血清 Cys C 水平升高与肺部空洞形成相关（OR = 1.426，95%CI：1.071-1.898）。
结论
肺结核患者血清 Cys C 水平升高与肺部空洞形成有关。
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