远程缺血预处理对多发性硬化症患者步行时心率反应的影响。
Effect of Remote Ischemic Conditioning on Heart Rate Responses to Walking in People with Multiple Sclerosis.
作者信息
Kai Xin Noelle Chung, Nair Krishnan, Chotiyarnwong Chayaporn, Baster Kathleen, Buckley Ellen, Mazza Claudia, Ali Ali, Baig Sheharyar
机构信息
Medical Student, The Medical School, The University of Sheffield, Beech Hill Road, Sheffield, United Kingdom.
Consultant Neurologist, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
出版信息
Ann Indian Acad Neurol. 2023 Jan;26(Suppl 1):S10-S14. doi: 10.4103/aian.aian_1091_21. Epub 2022 Aug 8.
BACKGROUND
Remote ischemic conditioning (RIC), exposure of body parts to brief periods of circulatory occlusion and reperfusion, has been shown to improve cardiovascular responses to exercise in healthy individuals but its effects in people with MS are unknown.
OBJECTIVE
This study aimed to assess the effect of RIC on heart rate responses to walking in people with MS.
DESIGN
Double blind randomized controlled trial.
SETTING
Multiple sclerosis clinic of tertiary care center teaching hospital in the United Kingdom.
METHODS
Three cycles of RIC were delivered by occluding the upper arm with a blood pressure cuff inflated to a pressure of 30 mmHg above the systolic blood pressure. In the sham group, the blood pressure cuff was inflated to 30 mmHg below diastolic blood pressure. Heart rate responses to the 6-minute walk test (6MWT), the tolerability of RIC using a numerical rating scale for discomfort (0-10), and adverse events were studied.
RESULTS
Seventy-five participants (RIC -38 and Sham-37) completed the study. RIC was well tolerated. Compared to sham, RIC significantly decreased the rise in heart rate ( = 0.04) and percentage of predicted maximum heart rate ( = 0.016) after the 6MWT.
CONCLUSION
RIC was well tolerated and improved the heart rate response to walking in people with MS. Further studies on RIC in the management of MS are needed.
背景
远程缺血预处理（RIC），即让身体部位经历短暂的循环阻塞和再灌注，已被证明可改善健康个体对运动的心血管反应，但其对多发性硬化症（MS）患者的影响尚不清楚。
目的
本研究旨在评估RIC对MS患者步行时心率反应的影响。
设计
双盲随机对照试验。
地点
英国一家三级护理中心教学医院的多发性硬化症诊所。
方法
通过将血压袖带充气至高于收缩压30 mmHg的压力来进行三个周期的RIC。在假手术组中，血压袖带充气至低于舒张压30 mmHg。研究了对6分钟步行试验（6MWT）的心率反应、使用不适数字评分量表（0-10）评估的RIC耐受性以及不良事件。
结果
75名参与者（RIC组38名，假手术组37名）完成了研究。RIC耐受性良好。与假手术组相比，RIC显著降低了6MWT后心率的升高（P = 0.04）以及预测最大心率的百分比（P = 0.016）。
结论
RIC耐受性良好，并改善了MS患者步行时的心率反应。需要对RIC在MS管理中的应用进行进一步研究。
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